0000000000037662
AUTHOR
Susanne Wagner
Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus?
Mantle Cell Lymphoma (MCL) is associated with a dismal prognosis. Recently, along with the improved understanding of the pathophysiology of this disease, new first line regimens have been established and in addition novel treatment options have entered the clinical arena. In consequence, prognosis of the disease has fortunately improved. We here focus on the rationale, current clinical knowledge and future concepts of Temsirolimus, an inhibitor of mTOR, in the treatment of MCL. At this time this drug has been shown to be effective as single agent for relapsed disease and early combination data show promising results. In addition, with a brief outline of other treatment options, we aim to g…
Totally new and pretty awesome : Amplifier–adjective bigrams in GloWbE
Abstract Previous work on adjectival intensification (e.g. very good , so glad , really great ) has mostly focussed on the adverbs in question, showing that different (native) varieties of English display distinctive preferences concerning intensifier choice. However, little is known so far about the role that intensifier-adjective units (bigrams) play. The present paper offers a first contribution to fill this research gap by focussing on a data-driven approach to (mostly) high-frequency bigrams and their collocational behaviour in the Corpus of Global Web-based English (GloWbE). Asymmetric and symmetric measures are employed to establish attraction and repulsion between adverb and adjecti…
Whyvery goodin India might bepretty goodin North America
AbstractSituated at the interface of several sub-disciplines (corpus linguistics, World Englishes, variationist sociolinguistics), this study investigates patterns of adjectival amplification (very good,so glad,pretty cool) in the Corpus of Global Web-Based English (GloWbE). It highlights regional distributions/preferences of amplifier-adjective 2-grams and the idiosyncratic status of certain bigrams according to their frequency status. Globally, clear regional preferences in amplification patterns as well as possible trends concerning change are identified. Regionally, L1 varieties contrast starkly with some regions (Africa, Indian subcontinent) but – maybe unexpectedly – not with others (…
Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease.
Patients with peripheral arterial disease (PAD) may develop a broad range of peripheral nerve dysfunctions including pain and sensory deficiencies due to chronic ischemia mostly involving the lower limbs. To investigate the degree of sensory abnormalities in such patients quantitative sensory testing (QST) might be a useful tool. Forty-five patients and 20 controls were enrolled in the present study and underwent QST according to the protocol of the German Research Network on Neuropathic Pain. PAD was graded according to the Rutherford classification. PAD patients were divided into two groups: 16 patients with critical limb ischemia (severe PAD) and 29 patients with intermittent claudicatio…
Never saw one – first-person null subjects in spoken English1
While null subjects are a well-researched phenomenon in pro-drop languages like Italian or Spanish, they have not received much attention in non-pro-drop languages such as English, where they are traditionally associated with particular (written) genres such as diaries or are discussed under a broader umbrella term such as situational ellipsis. However, examples such as the one in the title – while certainly not frequent – are commonly encountered in colloquial speech, with first-person singular tokens outnumbering any other person.This article investigates the linguistic and non-linguistic factors influencing the (non-) realisation of first-person singular subjects in a corpus of colloquia…