0000000000040159

AUTHOR

Midori Kato-maeda

showing 3 related works from this author

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

2021

24 páginas, 3 figuras, 1 tabla. The sequence data generated by this study has been deposited on SRA (https://www.ncbi.nlm.nih.gov/sra) under the accession number PRJNA670836. Extended data is available here: https://github.com/fmenardo/MTBC_L1_L3. DOI: https://doi.org/10.5281/zenodo.4609804 (Menardo, 2021).

0301 basic medicineMycobacterium tuberculosis / patogenicidadeTuberculosisGenotypevirusesLineage (evolution)030106 microbiologyLocus (genetics)adaptationBiologyGenomeGeneral Biochemistry Genetics and Molecular BiologyMycobacterium tuberculosis03 medical and health sciencesAdapta??oGenoma BacterianomedicineHumansOceano ?ndico / epidemiologiaGeneral Pharmacology Toxicology and PharmaceuticsAdaptationIndian OceanLocal adaptationGenetic diversityGeneral Immunology and Microbiologyvirus diseasesTuberculose / patologiaGeneral MedicineArticlesMycobacterium tuberculosisbiochemical phenomena metabolism and nutritionbiology.organism_classificationmedicine.diseasedigestive system diseases3. Good health030104 developmental biologyMycobacterium tuberculosis complexEvolutionary biologycoevolutionLinhagemCoevolutionResearch ArticleF1000Research
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Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development

2018

TheMycobacterium tuberculosiscomplex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise seven phylogenetic lineages that differ in their geographical distribution. There is growing evidence that this phylogenetic diversity modulates the outcome of TB infection and disease. For decades, TB research and development has focused on the two canonical MTBC reference strains H37Rv and Erdman, both of which belong to Lineage 4. Relying on only a few laboratory-adapted strains can be misleading as study results might not be directly transferrable to clinical settings where patients are infected with a diverse array of strains, includin…

Bacterial DiseasesResearch FacilitiesExtensively Drug-Resistant TuberculosisLineage (evolution)DiseaseAnimal PhylogeneticsMedicine and Health SciencesPhylogenyData Management0303 health sciencesGeographyPhylogenetic treeStrain (biology)QRGenomics3. Good healthActinobacteriaPhylogeneticsPhylogeographyInfectious DiseasesBiogeographyMycobacterium tuberculosis complexMedicineResearch LaboratoriesResearch ArticleComputer and Information SciencesTuberculosisTuberculosiScienceBiologyResearch and Analysis MethodsMycobacterium tuberculosis03 medical and health sciencesGenomic MedicineGeneticsmedicineTuberculosisHumansEvolutionary SystematicsTaxonomy030304 developmental biologyEvolutionary BiologyPopulation BiologyBacteria030306 microbiologyEcology and Environmental SciencesOrganismsBiology and Life SciencesGenetic VariationMycobacterium tuberculosisTropical Diseasesbiology.organism_classificationmedicine.diseaseGenòmicaPhylogenetic diversityEvolutionary biologyEarth SciencesZoologyPopulation Genetics
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Local adaptation in populations ofMycobacterium tuberculosisendemic to the Indian Ocean Rim

2020

AbstractLineage 1 (L1) and 3 (L3) are two lineages of theMycobacterium tuberculosiscomplex (MTBC), causing tuberculosis (TB) in humans. L1 and L3 are endemic to the Rim of the Indian Ocean, the region that accounts for most of the world’s new TB cases. Despite their relevance for this region, L1 and L3 remain understudied. Here we analyzed 2,938 L1 and 2,030 L3 whole genome sequences originating from 69 countries. We show that South Asia played a central role in the dispersion of these two lineages to neighboring regions. Moreover, we found that L1 exhibits signatures of local adaptation at theesxHlocus, a gene coding for a secreted effector that targets the human endosomal sorting complex,…

0303 health sciencesGenetic diversityTuberculosisbiology030306 microbiologyLocus (genetics)biology.organism_classificationmedicine.diseaseGenome3. Good healthMycobacterium tuberculosis03 medical and health sciencesMycobacterium tuberculosis complexEvolutionary biologymedicineGene030304 developmental biologyLocal adaptation
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