6533b873fe1ef96bd12d4a99
RESEARCH PRODUCT
Local adaptation in populations ofMycobacterium tuberculosisendemic to the Indian Ocean Rim
Chloé LoiseauChloé LoiseauRafael Silva DuarteMireia CoscollaMohamed SasamaloMohamed SasamaloMohamed SasamaloJerry HellaJerry HellaJerry HellaBijaya MallaBijaya MallaJulia FeldmannJulia FeldmannNiaina RakotosamimananaDorothy Yeboah-manuDaniela BritesDaniela BritesMiriam ReinhardMiriam ReinhardHelen CoxChristian BeiselSurakameth MahasirimongkolSurakameth MahasirimongkolPrasit PalittapongarnpimPrasit PalittapongarnpimLujeko KamwelaLujeko KamwelaLujeko KamwelaLevan JugheliLevan JugheliQian GaoMidori Kato-maedaA. L. Garcia-basteiroJanet A. M. FyfeSonia BorrellSonia BorrellVoahangy RasolofoChristophe SolaChristophe SolaIñaki ComasMoses JolobaH.-y. DouPhilip Noel SuffysSerej D. LeySerej D. LeySerej D. LeySebastian M. GygliSebastian M. GygliQingyun LiuMichaela ZwyerMichaela ZwyerFabrizio MenardoFabrizio MenardoLiliana K. RutaihwaLiliana K. RutaihwaK. V. Batista LimaGagneux SGagneux SEmilyn Costa ConceiçãoEmilyn Costa ConceiçãoKlaus ReitherKlaus ReitherD. G. De ViedmaHellen HizaHellen HizaLukas FennerLukas FennerLukas Fennersubject
0303 health sciencesGenetic diversityTuberculosisbiology030306 microbiologyLocus (genetics)biology.organism_classificationmedicine.diseaseGenome3. Good healthMycobacterium tuberculosis03 medical and health sciencesMycobacterium tuberculosis complexEvolutionary biologymedicineGene030304 developmental biologyLocal adaptationdescription
AbstractLineage 1 (L1) and 3 (L3) are two lineages of theMycobacterium tuberculosiscomplex (MTBC), causing tuberculosis (TB) in humans. L1 and L3 are endemic to the Rim of the Indian Ocean, the region that accounts for most of the world’s new TB cases. Despite their relevance for this region, L1 and L3 remain understudied. Here we analyzed 2,938 L1 and 2,030 L3 whole genome sequences originating from 69 countries. We show that South Asia played a central role in the dispersion of these two lineages to neighboring regions. Moreover, we found that L1 exhibits signatures of local adaptation at theesxHlocus, a gene coding for a secreted effector that targets the human endosomal sorting complex, and is included in several vaccine candidates. Our study highlights the importance of genetic diversity in the MTBC, and sheds new light on two of the most important MTBC lineages affecting humans.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-10-20 |