Author: Kenneth L. Mcclain

0000000000041181

AUTHOR

Kenneth L. Mcclain

0000-0003-0725-6263

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

BRAF-V600E expression is identified in hematopoietic progenitor and precursor myeloid dendritic cells in patients with high-risk LCH, and enforced expression of BRAF-V600E in CD11c+ cells recapitulates a high-risk LCH-like phenotype in mice.

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_3Experimental particle physics with accelerators
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  - PE2_10Atomic, molecular physics
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  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
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  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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  - PE1_6Geometry and global analysis
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  - PE1_10ODE and dynamical systems
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  - PE1_13Probability
  - PE1_14Mathematical statistics
  - PE1_15Generic statistical methodology and modelling
  - PE1_4 Algebraic and complex geometry
  - PE1_19Scientific computing and data processing
  - PE1_2Algebra
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  - PE1_21Application of mathematics in sciences
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  - PE1_5Lie groups, Lie algebras
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- PE11Materials Engineering
  - PE11_2Engineering of metals and alloys
  - PE11_1Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
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  - PE11_8Engineering of alternative established or emergent materials
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  - PE11_10Soft materials engineering, e.g. gels, foams, colloids
  - PE11_11Porous materials engineering, e.g. covalent-organic, metal-organic, porous aromatic frameworks
  - PE11_12Semi-conducting and magnetic materials engineering
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  - PE11_14Computational methods for materials engineering
LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
  - LS1_2Biochemistry
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  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
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  - LS1_9Molecular mechanisms of signalling processes
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  - LS2_1Genetics
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  - LS4_9Metabolism and metabolic disorders, including diabetes and obesity
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- LS3Cell Biology, Development, Stem Cells and Regeneration
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- LS5Neuroscience and Disorders of the Nervous System
  - LS5_1Neuronal cells
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  - LS5_5Neural networks and plasticity
  - LS5_10Ageing of the nervous system
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  - LS5_7Sensory systems, sensation and perception, including pain
  - LS5_13Nervous system injuries and trauma, stroke
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  - LS6_1Innate immunity
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SHSocial Sciences and Humanities
- SH2Institutions, Governance and Legal Systems
  - SH2_1Political systems, governance
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