BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

6533b7cefe1ef96bd12571b3

RESEARCH PRODUCT

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

Hitoshi Takizawa M. John Hicks Carl E. Allen Carl E. Allen Harshal Abhyankar Harshal Abhyankar Juliana Idoyaga Stephen J. Simko Stephen J. Simko Albert Ruzo Philip J. Lupo Philip J. Lupo Miriam Merad Björn E. Clausen Albert Shih Marie-luise Berres Tricia L. Peters Rikhia Chakraborty Rikhia Chakraborty Kenneth Heym Hélène Salmon Sergio A. Lira Matthew Collin Marylene Leboeuf Markus G. Manz Kenneth L. Mcclain Kenneth L. Mcclain Monique Beltrão Karen Phaik Har Lim Venetia Bigley Jeremy Price

subject

Male Pathology endocrine system diseases Cellular differentiation CD34 Antigens CD34 Mice 0302 clinical medicine Langerhans cell histiocytosis Bone Marrow Risk Factors Immunology and Allergy skin and connective tissue diseases Child 0303 health sciences Cell Differentiation 3. Good health Histiocytosis medicine.anatomical_structure Phenotype Treatment Outcome 030220 oncology & carcinogenesis Child Preschool Antigens Surface 2723 Immunology and Allergy Female Proto-Oncogene Proteins B-raf medicine.medical_specialty Immunology CD11c 610 Medicine & health Biology Article 03 medical and health sciences Germline mutation medicine Animals Humans Cell Lineage Genetic Predisposition to Disease Lectins C-Type Progenitor cell neoplasms 030304 developmental biology 2403 Immunology Histocompatibility Antigens Class II 302 Infant Correction Dendritic Cells medicine.disease Hematopoietic Stem Cells digestive system diseases CD11c Antigen enzymes and coenzymes (carbohydrates)Histiocytosis Langerhans-Cell Mannose-Binding Lectins 10032 Clinic for Oncology and Hematology Mutation Bone marrow

description

BRAF-V600E expression is identified in hematopoietic progenitor and precursor myeloid dendritic cells in patients with high-risk LCH, and enforced expression of BRAF-V600E in CD11c+ cells recapitulates a high-risk LCH-like phenotype in mice.

year	journal	country	edition	language
2014-01-01	The Journal of experimental medicine

10.1084/jem.20130977 https://pubmed.ncbi.nlm.nih.gov/25646268

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