0000000000041226

AUTHOR

Carmen Pérez-francés

showing 4 related works from this author

Maximal degree of airway narrowing induced by methacholine and adenosine monophosphate: relationship with the decrease in forced vital capacity.

2010

Background Changes in forced vital capacity (FVC) may represent an indirect method for the detection of plateau in response to inhaled bronchoconstrictor agents. Objective To determine the relationship between the level of plateau obtained with either methacholine or adenosine monophosphate (AMP) and the decrease in FVC induced by each bronchoconstrictor agent. Methods Airway responsiveness to high concentrations of methacholine and AMP was determined in patients with intermittent asthma (n = 41) or allergic rhinitis (n = 26). Furthermore, allergen-induced changes in the response to each bronchoconstrictor agent were investigated in 18 pollen-sensitive patients. Concentration-response curve…

Pulmonary and Respiratory MedicineAdenosine monophosphateAdultMaleVital capacitymedicine.medical_specialtyRhinitis Allergic PerennialBronchoconstrictionImmunologyVital CapacityBronchial Provocation TestsBronchoconstrictor Agentschemistry.chemical_compoundFEV1/FVC ratioInternal medicineImmunology and AllergyMedicineHumansIn patientMethacholine Chloridebusiness.industryrespiratory systemIntermittent asthmaMiddle AgedConfidence intervalAdenosine MonophosphateAsthmarespiratory tract diseaseschemistryAnesthesiaCardiologyPollenMethacholineFemaleBronchial HyperreactivitybusinessAirwaycirculatory and respiratory physiologymedicine.drugAnnals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology
researchProduct

Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a random…

2010

Abstract Background Little information is available on the effect of allergen-specific immunotherapy on airway responsiveness and markers in exhaled air. The aims of this study were to assess the safety of immunotherapy with purified natural Alt a1 and its effect on airway responsiveness to direct and indirect bronchoconstrictor agents and markers in exhaled air. Methods This was a randomized double-blind trial. Subjects with allergic rhinitis with or without mild/moderate asthma sensitized to A alternata and who also had a positive skin prick test to Alt a1 were randomized to treatment with placebo (n = 18) or purified natural Alt a1 (n = 22) subcutaneously for 12 months. Bronchial respons…

lcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinemedicine.medical_specialtyPathologyAllergybusiness.industrymedicine.medical_treatmentResearchInflammationGeneral MedicineImmunotherapyPlacebomedicine.diseaseGastroenterologyInternal medicineExhaled nitric oxidemedicineImmunology and AllergyMethacholineExhaled breath condensatemedicine.symptomAdverse effectbusinesslcsh:RC581-607medicine.drugAllergy, Asthma & Clinical Immunology
researchProduct

Effects of cigarette smoke on methacholine- and AMP-induced air trapping in asthmatics.

2014

Abstract Objective: No information is available on the effect of cigarette smoke on bronchoconstrictor-induced air trapping in asthma. The aim of this study was to evaluate the additional influence of smoking on methacholine- and adenosine 5'-monophosphate (AMP)-induced air trapping in subjects with asthma.Airway responsiveness to methacholine and AMP, bronchial (J'awNO) and alveolar (CANO) nitric oxide (NO) and exhaled breath condensate pH were measured in 68 adults (23 current smokers with asthma, 23 non-smokers with asthma and 22 current or former smokers with chronic obstructive pulmonary disease; COPD). The degree of air trapping induced by each bronchoconstrictor agent was expressed b…

Pulmonary and Respiratory MedicineAdultMaleVital capacityVital CapacityAir trappingNitric OxideBronchoconstrictor AgentsFEV1/FVC ratioPulmonary Disease Chronic Obstructiveimmune system diseasesSmokeTobaccomedicineImmunology and AllergyHumansExhaled breath condensateMethacholine ChlorideAsthmaCOPDbusiness.industrySmokingrespiratory systemMiddle Agedmedicine.diseaseAdenosine MonophosphateAsthmarespiratory tract diseasesBreath TestsAnesthesiaPediatrics Perinatology and Child HealthExhaled nitric oxideMethacholineFemalemedicine.symptombusinessmedicine.drugThe Journal of asthma : official journal of the Association for the Care of Asthma
researchProduct

Airway Responsiveness to Adenosine 5′-Monophosphate and Exhaled Nitric Oxide Measurements

2003

Objectives To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5′-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well controlled with a moderately high ICS dose. Methods A total of 37 patients with asthma well controlled for at least 3 months by treatment with a moderately high ICS dose (beclomethasone dipropionate, 500 to 1,000 μg or equivalent daily) were included in the study. Patients were treated for a 2-week run-in (baseline) period with their usual dose of ICS. For the next 12 weeks, patients were treated with ICS at half the previous d…

Pulmonary and Respiratory MedicineSpirometryInhalationmedicine.diagnostic_testbusiness.industrymedicine.drug_classCritical Care and Intensive Care Medicinemedicine.diseaseBronchodilatorAnesthesiaExhaled nitric oxidemedicineCorticosteroidBronchoconstrictionExpirationmedicine.symptomCardiology and Cardiovascular MedicinebusinessAsthmaChest
researchProduct