0000000000043474

AUTHOR

Hassan Khan

showing 16 related works from this author

Combined effect of sauna bathing and cardiorespiratory fitness on the risk of sudden cardiac deaths in Caucasian men : a long-term prospective cohort…

2018

Both cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) are each strongly and independently associated with sudden cardiac death (SCD) risk. However, the combined effect of CRF and FSB on SCD risk has not been previously investigated. We evaluated the joint impact of CRF and FSB on the risk of SCD in the Kuopio Ischemic Heart Disease prospective cohort study of 2291 men aged 42–61 years at recruitment. Objectively measured CRF and self-reported sauna bathing habits were assessed at baseline. CRF was categorized as low and high (median cutoffs) and FSB as low and high (defined as ≤2 and 3–7 sessions/week respectively). Multivariable adjusted hazard ratios (HRs) with confide…

saunafyysinen kuntocardiorespiratory fitnesssaunominenaerobinen suorituskykyäkkikuolemasydäntauditsudden cardiac death
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Standalone sauna vs exercise followed by sauna on cardiovascular function in non‐naïve sauna users: A comparison of acute effects

2021

Background and aimsSauna bathing and aerobic exercise have each been shown to affect cardiovascular function. However, direct comparisons between standalone sauna bathing and a combination of exercise and sauna on vascular indices remain limited. Therefore, we conducted a cross-over study using matched durations to explore the hemodynamic changes of sauna exposure when compared to a combination of aerobic exercise and sauna exposure.MethodsParticipants (N = 72) with at least one cardiovascular risk factor underwent, on two separate occasions: (a) a 30-minute sauna at 75°C (SAUNA) and (b) the combination of a 15-minute cycling exercise at 75% maximum heart rate followed by 15-minute sauna ex…

Acute effectsmedicine.medical_specialtyMean arterial pressurehypertensionsaunominenHemodynamicsvaltimotInternal medicinenon‐pharmocological therapyHeart ratekohonnut verenpainemedicineAerobic exerciseRisk factorResearch ArticlesAerobic exercisebusiness.industryRGeneral Medicineaerobinen harjoittelumedicine.diseaseverenpaineaerobic exerciseBlood pressureCardiologyArterial stiffnessMedicinelifestyle modificationnon-pharmocological therapybusinessarterial compliancefysiologiset vaikutuksetResearch ArticleHealth Science Reports
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Acute effects of exercise and sauna as a single intervention on arterial compliance

2019

verenpainekestävyysharjoittelusaunominenverenkiertofysiologiset vaikutukset
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Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study.

2018

Background Previous evidence indicates that sauna bathing is related to a reduced risk of fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate the relationship between sauna habits and CVD mortality in men and women, and whether adding information on sauna habits to conventional cardiovascular risk factors is associated with improvement in prediction of CVD mortality risk. Methods Sauna bathing habits were assessed at baseline in a sample of 1688 participants (mean age 63; range 53–74 years), of whom 51.4% were women. Multivariable-adjusted hazard ratios (HRs) were calculated to investigate the relationships of frequency and duration of sauna use with C…

kuolleisuusMalesaunominenPreventionlcsh:Rehkäisylcsh:MedicineGenderMiddle AgedCardiovascular diseaseSauna bathingRisk predictionsukupuoliSteam BathCardiovascular DiseasesRisk Factorssydän- ja verisuonitauditHumansennaltaehkäisyFemaleProspective StudiesRisk Reduction BehaviorResearch ArticleAgedProportional Hazards Models
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Leisure-time cross-country skiing and risk of atrial fibrillation and stroke:a prospective cohort study

2020

[No Abstract]

AdultMaleRiskmedicine.medical_specialtyEpidemiologyLeisure timeMEDLINEaivohalvausLeisure ActivitiesSkiingAtrial FibrillationmedicineHumansatrial fibrillationProspective StudiesProspective cohort studyStrokeFinlandCross countrybusiness.industryAtrial fibrillationleisure-timeMiddle Agedmedicine.diseaseeteisvärinähiihtostrokeStrokeEmergency medicineCardiology and Cardiovascular Medicinebusinesscross-country skiingvapaa-aika
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Sauna bathing reduces the risk of stroke in Finnish men and women : A prospective cohort study

2018

ObjectiveTo assess the association between frequency of sauna bathing and risk of future stroke.MethodsBaseline habits of sauna bathing were assessed in 1,628 adult men and women aged 53–74 years (mean age, 62.7 years) without a known history of stroke in the Finnish Kuopio Ischemic Heart Disease prospective cohort study. Three sauna bathing frequency groups were defined: 1, 2–3, and 4–7 sessions per week. Hazard ratios (HRs) (95% confidence intervals [CIs]) were estimated for incident stroke.ResultsDuring a median follow-up of 14.9 years, 155 incident stroke events were recorded. Compared with participants who had one sauna bathing session per week, the age- and sex-adjusted HR (95% CI) fo…

Malemedicine.medical_specialtysaunominenCardiovascular risk factors030204 cardiovascular system & hematologySteam Bath03 medical and health sciencesSauna bathing0302 clinical medicineRisk FactorsInternal medicinemedicineHumansProspective StudiesProspective cohort studyStrokeFinlandaivoinfarktibusiness.industryHazard ratioConfoundingcerebrovascular disordersta3142ta3121medicine.diseaseaivoverenkiertohäiriötcerebral infarctionConfidence intervalsauna bathingStrokeFemaleNeurology (clinical)Ischemic heartbusiness030217 neurology & neurosurgery
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SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…

Malepulmonary embolismInternationalitySettore MED/18 - CHIRURGIA GENERALEDeep veinVascular damage Radboud Institute for Health Sciences [Radboudumc 16]infectious diseasesCardiovascularSARS‐CoV‐2surgeryCOVID-19 ; SARS-CoV-2 ; deep vein thrombosis ; pulmonary embolism ; venous thromboembolismCohort StudiesPostoperative ComplicationsAnesthesiologyMedicine and Health SciencesProspective Studies610 Medicine & healthProspective cohort studyLung11 Medical and Health SciencesConfoundingHematologyMiddle AgedThrombosis17 Psychology and Cognitive SciencesCOVID-19; deep vein thrombosis; pulmonary embolism; SARS-CoV-2; venous thromboembolismPulmonary embolismCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolism.medicine.anatomical_structureCohortCOVID-19/complicationsPostoperative Complications/etiologyOriginal ArticleFemalePatient SafetyLife Sciences & BiomedicineCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolismHumanAdultmedicine.medical_specialtyAdolescentClinical Sciencesvenous thromboembolism610 Medicine & healthGlobalSurg CollaborativeVenous Thromboembolism/etiologydeep vein thrombosisNOCOVIDSurg CollaborativeYoung AdultMedicine General & InternalAge DistributionClinical ResearchCOVID‐19General & Internal MedicinemedicineHumansSex DistributionAgedScience & Technologybusiness.industrySARS-CoV-2PreventionNeurosciencesdeep vein thrombosiCOVID-19PneumoniaOdds ratioOriginal Articlesmedicine.diseaseSurgeryReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Prospective StudieGood Health and Well BeingAnesthesiology and Pain MedicineHuman medicinePostoperative ComplicationCohort StudiebusinessVenous thromboembolism[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Acute effects of exercise and sauna as a single intervention on arterial compliance

2019

MaleAcute effectsmedicine.medical_specialtyEpidemiologybusiness.industryMEDLINEArteriesMiddle AgedExercise TherapySteam BathCompliance (physiology)Cardiovascular DiseasesIntervention (counseling)Acute DiseasePhysical therapymedicineHumansFemaleVascular ResistanceExercise physiologyCardiology and Cardiovascular MedicinebusinessExerciseEuropean Journal of Preventive Cardiology
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Sleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality

2018

Background: Sleep duration has been shown to be associated with all-cause mortality, however its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease (CHD), sudden cardiac death, cancer related death and all-cause mortality. Methods Sleep duration was self-reported at baseline examinations performed between March 20, 1984 and December 5, 1989 in 2,361 men aged 42-61 years old from the Kuopio Ischemic Heart Disease study. Of these 1734 (73.4%) men were free from CHD and cancer at baseline. Results: A total of 802 all cause deaths, 202 fatal coronary heart disease events, 141 sudden cardia…

kuolleisuusmedicine.medical_specialtycancer deathDisease030204 cardiovascular system & hematologysudden cardiac deathSudden cardiac death03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicineMedicineäkkikuolemacoronary heart diseasebusiness.industryHazard ratioCancerta3142General Medicineta3121uni (biologiset ilmiöt)medicine.diseaseSleep in non-human animalsCoronary heart diseaseQuartilesydän- ja verisuonitauditCardiologysleep durationsyöpätauditbusiness030217 neurology & neurosurgery
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Short-term effects of Finnish sauna bathing on blood-based markers of cardiovascular function in non-naive sauna users

2018

Emerging evidence suggests that sauna bathing is associated with reduced risk of cardiovascular and all-cause mortality events. However, the biochemical pathways by which sauna bathing might confer its effects on cardiovascular function are not certain. We aimed to study the acute effects of Finnish sauna bathing on various blood-based cardiovascular biomarkers. The study included 102 non-naive sauna users (54% male) with mean age of 51.9 years, who had at least one cardiovascular risk factor. Participants underwent a 30-min single sauna session (mean temperature, 73 °C). Biochemical profiling was conducted before, immediately after sauna and 30-min post-sauna. Overall median N-terminal pro…

MaleAcute effectsBathingbiomarkkerit030204 cardiovascular system & hematologychemistry.chemical_compoundSauna bathing0302 clinical medicinecardiovascular diseaseNatriuretic Peptide BrainNatriuretic peptide030212 general & internal medicineFinlandbiologyIncidencearchitecture.styleMiddle AgedCardiovascular diseaseCardiac surgeryC-Reactive ProteinCardiovascular DiseasesarchitectureFemaleOriginal ArticleCardiology and Cardiovascular Medicinemedicine.medical_specialtymedicine.drug_classsaunominenCreatineexperimental studySteam Bath03 medical and health sciencesInternal medicineterveysvaikutuksetmedicineHumansRetrospective StudiesExperimental studybusiness.industrybiomarkersSauna bathingchemistryFinnish Saunasydän- ja verisuonitauditbiology.proteinCreatine kinasebusinessRisk Reduction BehaviorBiomarkersFollow-Up StudiesHeart and Vessels
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Combined Effect of Sauna Bathing and Cardiorespiratory Fitness on the Risk of Sudden Cardiac Deaths in Caucasian Men: A Long-term Prospective Cohort …

2018

Both cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) are each strongly and independently associated with sudden cardiac death (SCD) risk. However, the combined effect of CRF and FSB on SCD risk has not been previously investigated. We evaluated the joint impact of CRF and FSB on the risk of SCD in the Kuopio Ischemic Heart Disease prospective cohort study of 2291 men aged 42-61 years at recruitment. Objectively measured CRF and self-reported sauna bathing habits were assessed at baseline. CRF was categorized as low and high (median cutoffs) and FSB as low and high (defined as ≤2 and 3-7 sessions/week respectively). Multivariable adjusted hazard ratios (HRs) with confide…

MalePhysical fitness030204 cardiovascular system & hematologySudden cardiac deathCohort Studies0302 clinical medicineMedicineProspective Studiesäkkikuolema030212 general & internal medicineProspective cohort studyFinlandcardiorespiratory fitnessheart diseasesIncidenceHazard ratioAge FactorsVO2 maxta3142Middle Agedfyysinen kuntoCardiovascular Diseasesaerobinen suorituskykyCardiology and Cardiovascular MedicineCohort studyAdultsaunamedicine.medical_specialtysaunominenRisk AssessmentWhite Peoplesudden cardiac deathSteam Bath03 medical and health sciencesInternal medicineHumansAerobic exercisesydäntauditCardiorespiratory fitnessExercisebusiness.industryCardiorespiratory fitnessmedicine.diseasesauna bathingaerobic capacitySudden cardiac deathDeath Sudden Cardiacphysical fitnessSaunabusinessProgress in Cardiovascular Diseases
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Recovery from sauna bathing favorably modulates cardiac autonomic nervous system

2019

Objective: Sauna bathing is becoming a common activity in many countries and it has been linked to favorable health outcomes. However, there is limited data on the heart rate (HR) and heart rate variability (HRV) responses to an acute sauna exposure. Design: We conducted a single-group, longitudinal study utilizing a pre-post design to examine acute effects of sauna bathing on the autonomic nervous system as reflected by HRV. A total of 93 participants (mean [SD] age: 52.0 [8.8] years, 53.8% males) with cardiovascular risk factors were exposed to a single sauna session (duration: 30 min; temperature: 73 °C; humidity: 10–20%) and data on HRV variables were collected before, during and after …

MaleComplementary and Manual TherapyAcute effectssykemedicine.medical_specialtyLongitudinal studysaunominenCardiovascular risk factorsAutonomic Nervous SystemHealth outcomesSteam Bath03 medical and health sciencesSauna bathinglämpöhoito0302 clinical medicineHeart RateInternal medicineautonominen hermostoHeart ratemedicineHumansHeart rate variabilityLongitudinal Studies030212 general & internal medicineHeart rate variabilityCardiovascular responseAdvanced and Specialized Nursingbusiness.industryMiddle AgedHeat therapySauna bathingAutonomic nervous systemComplementary and alternative medicineCardiovascular DiseasesCardiologyFemalebusiness030217 neurology & neurosurgery
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Relative peak exercise oxygen pulse is related to sudden cardiac death, cardiovascular and all-cause mortality in middle-aged men

2018

Background Preliminary evidence suggests that peak exercise oxygen pulse – peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden cardiac death, fatal coronary heart disease and cardiovascular disease and all-cause mortality. Design A prospective study. Methods Peak exercise oxygen pulse was assessed in a maximal cycling test at baseline in 2227 middle-aged men of the Kuopio Ischaemic Heart Disease cohort study using expired gas variables and electrocardiograms. Relative peak exercise oxygen pulse was obtain…

MaleEpidemiologyDisease030204 cardiovascular system & hematologySudden cardiac deathrisk prediction0302 clinical medicineHeart RateRisk Factorscardiovascular diseaseCause of DeathMedicineProspective Studies030212 general & internal medicineäkkikuolemata315FinlandPulse (signal processing)Age FactorsVO2 maxta3141Stroke volumeta3142riskitekijätMiddle AgedPrognosispeak exercise oxygen pulseCardiovascular DiseasesCardiologyall-cause mortalityaerobinen suorituskykyCardiology and Cardiovascular MedicineCohort studymedicine.medical_specialtyOxygen pulsekuntotestitcardiopulmonary exercise testinRisk Assessmentsudden cardiac death03 medical and health sciencesOxygen ConsumptionSex FactorsPeak exercise oxygen pulsePredictive Value of TestsInternal medicineHeart ratecardiopulmonary exercise testingHumanssydäntauditbusiness.industrymedicine.diseaseDeath Sudden CardiacPhysical FitnessExercise Testsydän- ja verisuonitauditbusiness
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Prognostic Relevance of Cardiorespiratory Fitness as Assessed by Submaximal Exercise Testing for All-Cause Mortality: A UK Biobank Prospective Study

2020

Objective: To investigate if the inverse associations of cardiorespiratory fitness (CRF) with all-cause and cardiovascular mortality in the general population vary among individuals who are at different pre-test risk. Patients and Methods: CRF was assessed through submaximal bike tests in 58,892 participants aged 40-69 years who completed baseline questionnaires between January 1, 2006 and December 31, 2010 in the UK Biobank study. Participants were categorized into risk categories, which determined allocation to an individualized bike protocol. These were “minimal risk (1)”, “small risk (2)” and “medium risk (3)” groups (i.e., those who cycled at 50%, 35% of predicted maximal workload and …

AdultMaleUK Biobankmedicine.medical_specialtyDatabases FactualPopulationsubmaximal testRisk AssessmentMetabolic equivalentrisk predictionInterquartile rangeCause of DeathInternal medicinemedicineHumansProspective StudiesProspective cohort studyeducationAgedBiological Specimen Bankseducation.field_of_studycardiorespiratory fitnessFramingham Risk Scorebusiness.industryHazard ratioCardiorespiratory fitnessGeneral MedicineMiddle AgedPrognosisUnited KingdomCardiorespiratory FitnessCardiovascular DiseasesExercise Testall-cause mortalityFemaleRisk assessmentbusinessMayo Clinic Proceedings
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Sauna exposure leads to improved arterial compliance: Findings from a non-randomised experimental study.

2017

Background Heat therapy has been suggested to improve cardiovascular function. However, the effects of hot sauna exposure on arterial compliance and the dynamics of blood flow and pressure have not been well documented. Thus, we investigated the short-term effects of sauna bathing on arterial stiffness and haemodynamics. Design The design was an experimental non-randomised study. Methods There were 102 asymptomatic participants (mean age, 51.9 years) who had at least one cardiovascular risk factor. Participants were exposed to a single sauna session (duration: 30 min; temperature: 73℃; humidity: 10–20%). Pulse wave velocity, augmentation index, heart rate, blood pressure, mean arterial pres…

MaleTime FactorsEpidemiology030204 cardiovascular system & hematologyVentricular Function Left0302 clinical medicinePulse wave velocityMiddle AgedPulse pressurearterial stiffnessTreatment OutcomeCardiovascular DiseasesCardiologyFemaleCardiology and Cardiovascular MedicineArterial stiffnessComplianceheat therapyAdultheat therapymedicine.medical_specialtyMean arterial pressuresaunominenpulse wave velocityverenkiertoelimetPulse Wave Analysisverenkiertoexperimental studySteam Bath03 medical and health scienceslämpöhoitoVascular StiffnessInternal medicineHeart ratemedicineHumansbusiness.industryHemodynamicsBlood flowmedicine.diseasesauna bathingSurgeryCompliance (physiology)sauna bathingverenpaineBlood pressureArterial stiffnessbusiness030217 neurology & neurosurgeryfysiologiset vaikutuksetEuropean journal of preventive cardiology
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Cardiorespiratory Fitness and the Risk of Serious Ventricular Arrhythmias: A Prospective Cohort Study.

2019

Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-…

rytmihäiriötAdultMalemedicine.medical_specialtyRegression dilutionRisk AssessmentOxygen ConsumptionInterquartile rangeRisk FactorsInternal medicineMedicineHumansregression dilutionLongitudinal StudiesProspective StudiesRisk factorProspective cohort studyProportional Hazards Modelscardiorespiratory fitnessbusiness.industryIncidenceventricular arrhythmiasHazard ratioCardiorespiratory fitnessArrhythmias Cardiacta3142General Medicineta3121Middle Agedfyysinen kuntoBlood pressurerisk factorCardiorespiratory Fitnessmaximal oxygen uptakesydän- ja verisuonitauditCardiologybusinessBody mass indexMayo Clinic proceedings
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