6533b82cfe1ef96bd128ec51
RESEARCH PRODUCT
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
Dmitri NepogodievJoana Ff SimoesLi ElizabethMaria PicciochiJames C GlasbeyGlauco BaiocchiRuth Blanco‐colinoDaoud ChaudhryEhab AlameerKariem El‐boghdadlyFunmilola WuraolaDhruva GhoshRohan R GujjuriEwen M HarrisonHerman LuleHaytham KaafaraniMohammad KhosraviIrmgard KronbergerSezai LeventoğluHarvinder MannKenneth A McleanMengistu Gebreyohanes MengeshaMaria Marta ModoloFaustin NtirenganyaLisa NormanOumaima OutaniRiinu PiusPeter PockneyAhmad Uzair QureshiApril Camilla RoslaniSohei SatoiCatherine ShawAneel BhanguDmitri NepogodievOmar M OmarWaheed‐ul‐rahman AhmedLeah ArgusAlasdair BallAneel BhanguEdward P BywaterRuth Blanco‐colinoAmanpreet BrarDaoud ChaudhryBrett E DawsonIrani DuranMuhammed ElhadiJames C GlasbeyRohan R GujjuriConor S JonesEwen M HarrisonSivesh K KamarajahJames M KeatleySamuel LawdayLi ElizabethHarvinder MannElla J MarsonKenneth A McleanDmitri NepogodievLisa NormanRiinu OtsOumaima OutaniMaria PicciochiIrène SantosCatherine ShawJoana Ff SimoesElliott H TaylorIsobel M TroutChris VargheseMary L VennXu WilliamJoana Ff SimoesIrida DajtiArben GjataSalah Eddine Oussama KacimiLuis BoccalatteMaria Marta ModoloDaniel CoxPeter PockneyPhilip TownendFelix AignerIrmgard Elisabeth KronbergerElgun SamadovAmer AlderaziKamral HossainGreg PadmoreGabrielle RamshorstIsmaïl LawaniAnis CerovacSamir DelibegovicGlauco BaiocchiGustavo Mendonça Ataíde GomesIgor Lima BuarqueMuhammad GoharMihail SlavchevChukwuemeka NwegbuArnav AgarwalAmanpreet BrarJanet MartinJoshua Ng‐kamstraMaria Marta ModoloMaricarmen OlivosWenhui LouDong‐lin RenJose Andres CalvacheCarlos J Perez RiveraAna Danic HadzibegovicTomislav KopjarJakov MihanovicPablo Mijahil Avilés JiménezNikolaos GouvasJaroslav KlatRené NovysedlákNicolas AmisiPeter ChristensenAlaa El‐hussunaSylvia BatistaEddy Lincango‐naranjoSameh EmileDanilo Alfonso Arévalo SandovalHailu DhuferaSamuel HailuMengistu G MengeshaJoonas H KauppilaAlexis P ArnaudZaza DemetrashviliMarkus AlbertsmeierHans LederhuberMarkus W. 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FayadAsmaa RadwanAsser SallamMoataz SallamAhmad ShokryAhmed Mohamed FaroukAhmed ShehtaAhmed ElfallalHossam ElfekiMohamed ElsaeedMahmoud ElsaidSameh EmileAmany MakroumDina Mohamed ElsaidMohamed MostafaMohamed W OmarMohamed RezkAhmed SakrAly SanadMostafa ShalabyMohammed ShawqyMohamed ShetiwyAshraf ShomaNoura TawaklAsmaa YunesMohamed AbdelkhalekAmr AbouzidKhalid AtallahRami ElmorsiAhmed ElsherbiniKhaled GaballaOmar HamdyMohamed HamdyIslam Hany MetwallyBasel RefkyMosab ShetiwyMohammed ZuhdyMohammed A ZahranFatima AbdellahAhmed AbdelmawlaAhmed AbdrabouAsmaa AbubakrRawda Al GoharyMohammed Hamdy Al‐shazlyMohamed AliAbdallah R AllamAya AposaeedaMohammed AsfourAmmar AymanAbdelrahman Azzam OmranIbrahim Tawfiq DaghashMahmoud Ahmed EbadaTaher EidAhmed El KelanyEsraa El ShemyMohammed El‐hag‐alyOmar ElgamalMahmoud ElghouryAhmed Farag ElkasedTakwa Hamed EllakwaHamed EllakwaAmr ElmeanawySalma ElnoamanyAlaa ElsabaghAbdelrahman ElsaweyEnas ElshabrawySeliman ElshakhsNaira ElsoudyEsraa EzzatAhmed FawzyAbrar GamalAhmed GameelKhaled GharbiaMohamed GhonaimAlaa GhonaimAhmed HafezAbdelrahman HafezZainab IsmailMohamed KhaledMohammed MeselhyPola MikhailMervat MohamedMohamed MougahedAbdulla MustafaAhmed NadaJanna OmranMohamed S. 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LeeFlorian N LochChristian SchineisIlgar AghalarovOrlin BelyaevChris BraumannAnnika EnsteTim FahlbuschTorsten HerzogPhilipp HöhnJulian HornJulia JedanowskiJulia KnipschildAndreas Minh LuuPrem Vignesh MohanLeonie SiemenIllya SlobodkinJohanna Josefine StrotmannWaldemar UhlKaterina WolfMark CoburnEva EggerKlaus EichhornJana EnderesFrederick FarAlina FranzenTim R. GlowkaErdem GüresirAlexis HadjiathanasiouJörg C. KalffZaki KohistaniSteffen ManekellerAlexander MusteaChris ProbstThomas RandauFlorian ReckerPatrick SchussNadine Straßberger‐nerschbachSebastian StriethHendrik TreedeCornelius J. BeekumHartmut VatterMarkus VeltenTim O. VilzDieter WirtzMaria WittmannMichael BehrDirk Rolf BulianBenedikt MarcheTobias MoczkoRobin OtchwemahSissy‐amelie SchulzPanagiotis ThomaidisChristiane BrunsClaus CursiefenChristian DomröseHans FuchsLudwig Maximilian HeindlMichael R. 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BaderAnna Eleonora GutStephanie OttlAlexandra Viktoria BehrAlexandros DiamantisAndreas FichterJens GemptFlorian GrillMatthias HeckDaniel JiraMichael KallmayerFlorestan KollStefan LuhneBernhard MeyerRobert PatachiaIlaria PergoliniDaniel ReimSeyer SafiChristoph SchäfferMoritz SchirrenArthur WagnerHelmut WegmannMarkus WirthZhaojun ZhuUghur AghamaliyevMarkus AlbertsmeierMahmoud AlmaghrabiWolfgang BöckerJan BruderKonstantin FrankViktoria HerterichVerena HuberMatthias IlmerChristian KammerlanderAlexander M. KepplerCarl NeuerburgViktor H. Ehrlich‐treuenstättJens WernerNikolaus BörnerFlorian FeggDaniela HartmannRoland LadurnerParis LiokatisKathrin PatzerJustin Gabriel SchlagerWenko SmolkaPetra ZimmermannRudolf HatzDiana SteinhartMircea Gabriel StoleriuClaudio GlowallaTim SaierDorien SchneidmuellerKarl Wilhelm HenkelJosef StadlerMartin SteinerKatharina HölzJulia Christina KaiserChristian KnorrStefan M. 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AljubaRoaa AljunaidiTareq AlzughayyarAdham AmroSarah AmroMays DweikSafa HalmanQutaiba QafishaFarah ShaheenBalqis ShawerDaleen ShehadehJihad ZalloumKhaled DemyatiMohammed HajhamadZain SaqfalhaitEmmy Arrue Del CidMoises CukierHomero Rodriguez‐zentnerFrancisco AbedRafael Osmar Adorno GarayoRuben AguilarAna AguilarDomingo Javier Aguilera MaidanaDiego José Almada CasañasTeresa AlmironAnalia ArruaPedro AvilaBrenda BalmacedaAlexandra BarretoAnaly Barreto GaleanoBelinda Barrientos NuñezMagdalena BenegasMartin BerdenAmalia BogarinJorge BonninEdulfo Britez BarriosJulio BurgosCarlos Fabián Cárdenas MelgarejoJosé De Jesus Casco SamudioSandra CataldiJorge Augusto CenturionLuz Maria Cespedes RamirexKaterine ColinaGabriel Augusto Cuevas AlmandoKarina De BleeckerAntonella DragottoEiji EiwaJuan Carlos EncisoCarla EspinolaLujan EstigarribiaCelso Ariel FernandezRocio FerreiraBlas FigueredoDaniel FleitasClaudia FretesMartin FretesWalter Rene Fretes GonzalezHumberto Nicolas Galleano RuizJulio GautoClaudia GautoViviana GomezNadia GómezOsvaldo InsfranLiz KarinaChristian LegalOscar LlanesWalter MartínezWalter Rodrigo Martínez TorresKiichiro MatsumuraEsteban Daniel Mendoza GalvánLeila Mereles NogueraSergio MoraDaniel NavarroLidia Noguera RomanAnalia NúñezLorena OcamposAlma Maria Ojeda RojasDerlis Joel Ojeda VillasboaJuan PalaciosJessica Pamela Portillo SosaRossana RamírezGerman RamosDiego SamudioJorge Eduardo Sisa AcostaRodney TellezPorfiria UrquhartBeatriz VeraJorge David Vera FlorentinDaniel VidalletGilce Teresita VillalbaJacob VömelLaura AquinoMarisa Natalia MartinezCesareo Saldivar PatiñoOmar AguayoMaria Esther Ferreira AguileraFederico GarcíaMaria GiangrecoDerlis OsorioCynthia Marlene Rodríguez SosaPaulo VillanuevaSandra Elizabeth Centurion RolonRozana OharaJuan Marcelo PortilloRuben Milciades Varela CanoJuan Manuel Baez MelgarejoFrancisco Vidal CandiaCarlos ChiricoSofia Belen Diaz PinedaDiego Alfonso Paiva VeraAyrton Facundo ValdovinosDahiana Fatima VelazquezDiego Raul Abente ArriolaAnalia BritosDaniel CanteroJessica CenturiónCelso Ariel FernandezRicardo Ignacio Olmedo BareiroDayhana DuarteSusana ParedesCarlos Pfingst RojasAngel Luis Agüero DelgadoJuan Marcelo Delgado GodoyHelmut Alfredo Segovia LohseOscar BenitezVictor LuraschiJoel MolinasDulce AñascoAlejandro Arévalo BarretoCristhian Chavez RivaldiMartin ChenuLuz GarciaRosana GodoyV Gustavo Miguel MachainMaria Jose Martinez VelázquezBrayan David Pedroso AlvarengaAgustin Rodriguez GonzalezRosa SánchezMaría Liz SánchezHerald Rene Segovia LohseCesar Giuliano Sisa SegoviaOsmar CuencaSara MelgarejoEver David Sosa FerreiraGlenda Marina Falcon PachecoEstefany Angela Flores AnayaEvy Yamil Huaman HuallancaKarla Melissa Marchan PalmaRobinson Mas MelendezLiliam PalominoArazzelly Del Pilar Paucar UrbinaJorge OrdemarManuel QuirozJose Rios ChiuyariVictor Diego Caballero SarabiaCarlos Eduardo Otiniano AlvaradoLorena Fuentes Rivera LauChristian LozanoDavid TorresHenry Rafael Acosta CastroGabriel Bayona‐alvaradoGiuliano Borda‐luqueJoao CruzGrecia LizzettiVictor Vasquez MoralesMilagros Niquen‐jimenezMartin OrmeñoLiz OrtizKewin Quispe RocaDarwin Artidoro Quispe‐cruzEdgar SanzSebastian Shu YipKatherine Tataje PomaXimena Paola Vasquez OjedaGaby Susana Yamamoto SetoClaudia AriasCarlos PalaciosJuan Francisco Pintado MejiaJose Maria Silva BarandiaranEduardo HuamanGuillermo Enrique Reyes GamonalClaudia Suazo CarmeloSergio ZegarraJenner Betalleluz PallardelDiana Lizet Cruz CondoriJose Vasquez ValverdeEduardo HuamanRegina Amparo Ugarte OsccoCesar Alberto Vergel CabreraConsuelo DiazGian MendiolaAngie Paredes CaturinyAdolfo SalazarJoel Jesús Sánchez EstupiñanMarco Sandoval VaezRoy ArangoytiaFrancisco BerrospiJorge Luis Bustamante PoloJimmy Cárdenas CoaquiraFernando Cárdenas EscalanteDarwin Oliver Desposorio ArmestarSheyla Katherine Diaz MoraJheff LauraAldo Lopez BlancoKaroll Tatiana Meza GarciaJaime MorenoEduardo PayetJoan Perez VillenaDaniel CardenasYahaira Tatiana Carpio ColmenaresLuis Alcides García BarrionuevoMiguel Roberto Li ValenciaPercy Mansilla DoriaFiorella Palomino EscalanteMónica Falcón CoronadoCarlos Shiraishi ZapataPamela Valderrama RochaUlbar EdinsonMaria Rosa OrtizVladimir Laureano Velasquez HuarcayaAndrei Cesar AbellaMa NullCarmela AndalWillmar AnosoMonica Maria BejasaAldrin CuasayJesus FernandezEunice MercadoAmabelle MorenoAlejandro PalinesTrina RegaladoCristeta UniraClarence Pio Rey YacapinCarlo Angelo CajucomMary Anne Carol CuetoCharmagne Loren RamosAvril DavidJohn Isaac MerinAlberto RoxasNipseey Pauloe CandelarioMarc Paul LopezRamon Alberto RamosKhrissa Lea Elisa ViolagoYvann Kenneth BenosaLouie Czelline De LeonMarlow EsguerraRene Luis FilarcaCorina GaddiPatrick Jovan GagnoJeffy GuerraAngelica Aubrey MorlaRivero OpanoEdgardo PensergaMark Jheric TesilHazel TuringanJoel AldanaAlyssa Carmina AlmelorJaime Jr AlmoraAngeli Anne AngMaria Angelica AradaJeric ArbizoDiana BarrettoRonnie BaticulonKevin Ivan P. ChanElmer Jason CruzPauleen GranoJuan Gabriel De LeonJojiemar De PanoMaria Angela DealinoDaryl Anne MundoHans Jesper Del MundoCzarlo Dela VictoriaJuan Miguel Roberto DelgadoJan Erik DetranRobert Zaid DiazEdward Arlu DinoyEfren DomingoHeather Grace DulnuanDumlao PatricioCarlo ElisesEmmanuel EstrellaJoan Marie FlorGrace GanaGo Bynlee StuartAna Melissa Hilvano‐cabungcalJacinto CesarJan Alexeis LacuataMarie Carmela LapitanRenee Leen LaudatoGerardo LegaspiLi RyleLiana Mae LoboClaudine LukbanChristopher John MacapugayNikko MagsanocEnrique ManalangJon‐alexis MontemayorJaysonnel NotarioMarie Dione SacdalanJan Armelynn SantosAbigail SarmientoDennis SerranoSamantha SiahetiongKrisniel Florence SolisDenorson SotalboErik TongolGermaine UrsabiaUy Patricia AnnCharmaine Grace ValerosKaren Joyce VelascoVincent VenidaHans Edison YapMario Angelo ZamoraAnika Johanna AgoncilloDavid Vincent AntonioNicole Robyn BangayanMarinelle CastroGrace Lynn EstanislaoAnne Kathleen Ganal‐antonioFaiyazudin Amado IbrahimPeter JarinLaine Valerie Kongsun ChingJosephine Alexandra LimMariles NazalAmanda May Ong VañoLouie RacelisKirsten RamosJeryl Anne Silvia ReyesRon Daniel RiveraJose Antonio SaludElva Marita SarteSy Dale KingsleyEileen Grace TancincoAnna Mariel TorioUy Avegail NiñaRyan Rainiel AbaryDabalos JesusVincent SiquianKenneth YabutJose Carlos BarcelonMa NullInez CarballoJo Ann ChiuAeris Jane D. NacionPiotr MajorMichał PędziwiatrJustyna RymarowiczMarcin BobińskiJan KotarskiKarolina Rasoul‐pelińskaKonrad FutymaPawel MiotlaEwa RechbergerBogdan KoczyKarol SzylukPedro BotelhoMariana Branco LopesBrigitta CismasiuPaulo Matos CostaJean‐michel FallahGonçalo Teodoro Fernandes FreitasFilipa FerreiraJosé Guilherme Gonçalves NobreSusana HenriquesRui LinoAlexandre MacedoCláudia MendesAna Lúcia Preto BarreiraNuno RamosSusana Candeias RodriguesCatarina Rolo SantosRicardo São PedroMelissa SilvaCarla SousaRui RibeiroJosé SantosOctavio ViveirosRicardo AlvesPedro SerralheiroTobias TelesLiliana B. 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Malepulmonary embolismInternationalitySettore MED/18 - CHIRURGIA GENERALEDeep veinVascular damage Radboud Institute for Health Sciences [Radboudumc 16]infectious diseasesCardiovascularSARS‐CoV‐2surgeryCOVID-19 ; SARS-CoV-2 ; deep vein thrombosis ; pulmonary embolism ; venous thromboembolismCohort StudiesPostoperative ComplicationsAnesthesiologyMedicine and Health SciencesProspective Studies610 Medicine & healthProspective cohort studyLung11 Medical and Health SciencesConfoundingHematologyMiddle AgedThrombosis17 Psychology and Cognitive SciencesCOVID-19; deep vein thrombosis; pulmonary embolism; SARS-CoV-2; venous thromboembolismPulmonary embolismCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolism.medicine.anatomical_structureCohortCOVID-19/complicationsPostoperative Complications/etiologyOriginal ArticleFemalePatient SafetyLife Sciences & BiomedicineCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolismHumanAdultmedicine.medical_specialtyAdolescentClinical Sciencesvenous thromboembolism610 Medicine & healthGlobalSurg CollaborativeVenous Thromboembolism/etiologydeep vein thrombosisNOCOVIDSurg CollaborativeYoung AdultMedicine General & InternalAge DistributionClinical ResearchCOVID‐19General & Internal MedicinemedicineHumansSex DistributionAgedScience & Technologybusiness.industrySARS-CoV-2PreventionNeurosciencesdeep vein thrombosiCOVID-19PneumoniaOdds ratioOriginal Articlesmedicine.diseaseSurgeryReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Prospective StudieGood Health and Well BeingAnesthesiology and Pain MedicineHuman medicinePostoperative ComplicationCohort StudiebusinessVenous thromboembolism[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologydescription
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly. ispartof: ANAESTHESIA vol:77 issue:1 pages:28-39 ispartof: location:England status: published
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-12-07 |