0000000000693511
AUTHOR
Francesco Corcione
Everolimus as first line therapy for pancreatic neuroendocrine tumours: current knowledge and future perspectives
urpose Everolimus has been shown to be effective for advanced pancreatic neuroendocrine tumours (pNETs), but its positioning in the therapeutic algorithm for pNETs is matter of debate. Methods With the aim to shed light on this point, we performed an up-to-date critical review taking into account the results of both retrospective and prospective published studies, and the recommendations of international guidelines. In addition, we performed an extensive search on the Clinical Trial Registries databases worldwide, to gather information on the ongoing clinical trials related to this specific topic. Results We identified eight retrospective published studies, two prospective published studies…
Individualisierte Chirurgie des Magenkarzinoms
Die chirurgische Behandlung beim Magenkarzinom besteht aus ablativen und rekonstruktiven Phasen. Die wesentlichen Phasen der Operation sind: 1. Ablosung des Omentum majus vom Querkolon und Eroffnung der Bursa omentalis, 2. Mobilisierung und Durchtrennung des Bulbus duodeni, 3. Mobilisierung des Magens entlang der grosen Kurvatur, 4. Mobilisierung des Magens entlang der kleinen Kurvatur, 5. Retrogastrale Mobilisierung und Durchtrennung der A. gastrica sinistra, 6. Durchtrennung des Magens bzw. Mobilisierung und Durchtrennung des Osophagus, 7. Lymphadenektomie (meist in Kombination mit anderen Schritten), 8. Rekonstruktion der Passage. Die Reihenfolge der Operationsschritte variiert in Abhang…
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…
The treatment of hyperinsulinemic hypoglycaemia in adults: an update
Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. New approaches to treatment of HH are available including mini-invasive sur…