6533b82ffe1ef96bd1294872
RESEARCH PRODUCT
The treatment of hyperinsulinemic hypoglycaemia in adults: an update
M. V Davi′A. PiaV. GuarnottaG. PizzaA. ColaoA. FaggianoNull On Behalf Of Nike GroupManuela AlbertelliEmanuela ArvatRoberto BaldelliAlfredo BerrutiAntonio BianchiLisa BodeiGerardo BottiFrancesco CorcioneGianfranco Delle FaveLaura De Marinis GrassoGaetano De RosaAntonella Di SarnoAlessandra DicitoreNicola FazioGiuseppe FanciulliPiero FerollaDiego FeroneAngelina FiliceMarco GalloCarla GiordanoDario GiuffridaAndrea LaniaSecondo LastoriaFrancesco LogolusoPaola LoliPasqualino MalandrinoMarco ManzoniMassimo MarchettiChiara MartiniErika MessinaRoberta ModicaCecilia MottaMauro PapottiStefano PartelliGiovanni PersicoAlessandro PiovesanAlfredo PontecorviValeria RamundoPaola RazzoreFrancesca RotaFrancesco ScavuzzoConcetta SciammarellaGiovanni VitaleMaria Chiara Zatellisubject
Adultmedicine.medical_specialtyPediatricsendocrine system diseasesEndocrinology Diabetes and MetabolismGastric bypassNesidioblastosis030209 endocrinology & metabolismHypoglycemiaSettore MED/13 - Endocrinologia03 medical and health sciences0302 clinical medicineEndocrinologyHyperinsulinismmedicineHyperinsulinemic hypoglycaemiaHumansAutoimmune hypoglycaemiaInsulinomaEverolimusbusiness.industryAutoimmune hypoglycaemia; Hyperinsulinemic hypoglycaemia; Insulinoma; Nesidioblastosis; Treatment; Adult; Humans; Hyperinsulinism; HypoglycemiaAutoimmune hypoglycaemia; Hyperinsulinemic hypoglycaemia; Insulinoma; Nesidioblastosis; Treatment; Adult; Humans; Hyperinsulinism; Hypoglycemia; Endocrinology Diabetes and Metabolism; EndocrinologySettore MED/13 - ENDOCRINOLOGIANesidioblastosimedicine.diseaseHypoglycemiaSurgeryDiabetes and MetabolismTreatmentNesidioblastosisAutoimmune hypoglycaemia; Hyperinsulinemic hypoglycaemia; Insulinoma; Nesidioblastosis; Treatment030220 oncology & carcinogenesisAutoimmune hypoglycaemiaInsulinomaAutoimmune hypoglycaemia; Hyperinsulinemic hypoglycaemia; Insulinoma; Nesidioblastosis; Treatment; Endocrinology Diabetes and Metabolism; EndocrinologyDifferential diagnosisbusinessHyperinsulinismhormones hormone substitutes and hormone antagonistsmedicine.drugHumandescription
Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-13 |