The signature of longevity in Sicily

Ageing is a natural and physiological condition that is the result of compromised stress response, homeostatic imbalance and increased risk of developing diseases. However, if aging with good health and functions (successful ageing) and aging with disease and disability (unsuccessful ageing) depends on a combination of “positive features”, including genetic, epigenetic and phenotypic characteristics in combination with favourable environment, economic status and social involvement. In our study, we summarize some key points for the identification of a longevity signature, with a particular focus on long-living Sicilian individuals and centenarians. Analysing three different Sicilian cohorts…

Connexin 37 1019 gene polymorphism in myocardial infarction patients and centenarians.

Role of polymorphisms of CC-chemokine receptor-5 (CCR5) gene in acute myocardial infarction and biological implications for longevity.

CD4+CD25+ regulatory cells in aged people are related to IL-10 genetic background and have effect on CMV-specific CD8 lymphocytes