0000000000046646

AUTHOR

Bryan C. Good

showing 2 related works from this author

Physiological Micromechanics of the Anterior Mitral Valve Leaflet

2011

An improved understanding of mitral valve (MV) function remains an important goal for determining mechanisms underlying valve disease and for developing novel therapies. Critical to heart valve tissue homeostasis is the valvular interstitial cells (VICs), which reside in the interstitium and maintain the extracellular matrix (ECM) through both protein synthesis and enzymatic degradation [1]. There is scant experimental data on the alterations of the MV fiber network reorganization as a function of load, which is critical for implementation of computational strategies that attempt to link this meso-micro scale phenomenon. The observed large scale deformations experienced by VICs could be imp…

Coupling (electronics)Extracellular matrixMaterials sciencemedicine.anatomical_structureMitral valvemedicineMicromechanicsMechanotransductionHomeostasisFunction (biology)Cell biologyMitral valve leafletBiomedical engineeringASME 2011 Summer Bioengineering Conference, Parts A and B
researchProduct

Alterations in the Microstructure of the Anterior Mitral Valve Leaflet Under Physiological Stress

2012

An improved understanding of mitral valve (MV) function remains an important goal for determining mechanisms underlying valve disease and for developing novel therapies. Critical to heart valve tissue homeostasis is the valvular interstitial cells (VICs), which reside in the interstitium and maintain the extracellular matrix (ECM) through both protein synthesis and enzymatic degradation [1]. There is scant quantitative experimental data on the alterations of the MV fiber network reorganization as a function of load, which is critical for implementation of computational strategies that attempt to link this meso-micro scale phenomenon. The observed large scale deformations experienced by VICs…

Extracellular matrixMaterials sciencemedicine.anatomical_structureMitral valvemedicineFiber networkMechanotransductionHeart valve tissuePhysiological stressHomeostasisCell biologyBiomedical engineeringMitral valve leafletASME 2012 Summer Bioengineering Conference, Parts A and B
researchProduct