0000000000049370
AUTHOR
Sébastien Amoureux
Serum brain-derived neurotrophic factor and platelet activation evaluated by soluble P-selectin and soluble CD-40-ligand in patients with acute myocardial infarction
Little is known about the role of neurotrophins (NT) under adult vascular homeostasis in normal and pathological conditions. The NT family, including nerve growth factor and brain-derived neurotrophic factor (BDNF) are expressed in atherosclerotic vessels. Previous studies demonstrated that plasma BDNF levels were increased in the coronary circulation in patients with unstable angina. However, the role of BDNF during the onset and evolution of unstable angina remains to be elucidated. The objective of this study was to evaluate the relationship between BDNF, functional parameters and biological markers associated with inflammatory processes and platelet activation. BDNF serum levels were as…
C023 Evaluation de l’effet protecteur de l’acide dihydro-lipoïque vis-à-vis d’une séquence d’ischémie-reperfusion sur coeur isolé perfusé de rat et d’un stress oxydant induit in vitro sur le globule rouge
L’acide alpha-lipoique (AL) est un dithiol endogene aux proprietes antioxydantes. Au niveau intracellulaire, l’AL subit une reduction pour former l’acide dihydro-lipoique (DHLA) qui represente son metabolite le plus actif. L’objectif de ce travail a ete de preciser les effets d’un traitement in vitro par le DHLA sur 1) des coeurs isoles perfuses de rats soumis a une sequence d’ischemie-reperfusion (IR) et 2) des globules rouges (GR) soumis a une agression radicalaire. Les coeurs ont ete isoles, perfuses en mode Langendorff et soumis a une ischemie globale totale de 30 min suivie d’une reperfusion de 30 min. Cinq minutes avant l’ischemie et pendant toute la periode de reperfusion, il a ete a…