Viscosimetric investigation of the interaction between sodium dodecylsulfate micelles and a polymer drug carrier

Abstract The viscosities of aqueous sodium dodecyl sulfate solutions with and without α,β-poly( N -hydroxyethyl)- dl -aspartamide (PHEA), at 15, 25 and 35°C are reported. The viscosities of SDS and of PHEA aqueous solutions are discussed in terms of the parameter D [D = ( η η 0 − 1)/φ] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solutions, discussed in terms of the parameter F [ F = η rel ( PHEA ) + η rel ( SDS ) − η rel ( SDS + PHEA )] M , demonstrate the occurrence of interactions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.

Reaction of α,β-poly(N-hydroxyethyl)-DL-aspartamide with derivatives of carboxylic acids

Synthesis of polycyclic fused benzimidazole derivatives

Am easy method for the synthesis of tetraeyclie systems containing an imidazole and an iso-thiazole or an imidazole and a thiazine ring, by reacting 2H-1,3-benzothiazine-2-thion-4(3H)one with aromatic primary diarnines is reported. The structures were assigned based upon mass spectra and modes of cleavage of the compounds. The most important fragments are described.

Synthesis of 5H-[1,2]-benzisothiazolo[2,3-a]quinazolin-5-one

Addition reactions of azoesters with 2-thioquinazolinones

Reaction between diethyl azodicarboxylate (I) and 1,2,3,4-tetrahydro-2-thioquinazolin-4-one (II), as a cyclic model of thiourea, both in alcoholic medium and in inert solvents has been investigated. By carrying out the reaction in an inert solvent, it was possible to isolate an intermediate. Evidence is presented that the intermediate, in turn, was converted into the final products. Structures were unequivocally assigned by mass spectrometry.

Synthesis of some derivatives of 4(1H)quinazolinones

Informal caregiving burden in advanced non-small cell lung cancer: the HABIT study.

Introduction This study's aim was to assess economic data regarding the home assistance burden for advanced non-small cell lung cancer (NSCLC) patients in Italy. Patients and Methods One hundred four NSCLC patients in second-line chemotherapy (2LC) or in supportive therapy (ST) were enrolled in 18 Italian oncology departments and were observed for 3 months. The main caregiver's workload was assessed monthly by a task scale; other caregivers' activities were also registered. Eastern Cooperative Oncology Group performance status was assessed by physicians, and patients completed the Lung Cancer Symptoms (LCS) subscale. Formal caregiving time was valued according to market prices; informal car…

The behaviour of some thioxanthene and thianthrene derivatives with hydrazoic acid