Dopplersonographische Blutflußmessung der A. umbilicalis: Ist ein Screening sinnvoll?

251 Einlingsgraviditaten mit gesichertem Gestationsalter wurden zwischen der 28. und 42. Woche p.m. dopplersonographisch untersucht. Die Flusmuster der Nabelarterien wurden durch Bestimmung der A/B-Ratio nach Stuart anhand einer eigenen Normkurve ausgewertet. Als pathologisch wurden Werte oberhalb der gestationsalterbezogenen 95. Percentile angenommen. Die Messungen wurden mit einem gepulsten Dopplersonographiegerat der FA SMS durchschnittlich 2 Wochen antepartal durchgefuhrt.

Dopplersonographische Blutflußmessung der A. umbilicalis: Ist ein Screening sinnvoll?

Umbilical artery blood flow velocity waveforms during variable decelerations of the fetal heart rate

Blood flow velocities of the umbilical arteries were measured by Doppler ultrasonography during variable decelerations of the fetal heart rate. The flow velocity waveforms, being normal between uterine contractions, showed either an unchanged flow velocity waveform with an exclusive fetal heart rate effect on end-diastolic velocities or a rapid change to absent and reverse diastolic flow during the decelerations, indicating an abrupt increase in placental resistance with a halt in placental perfusion. Computer-aided reconstruction of the fetal heart rate curve revealed the exact temporal relationship between the reduction of umbilical artery perfusion and deceleration of fetal heart rate. W…

Low target birth weight or growth retardation? Umbilical Doppler flow velocity waveforms and histometric analysis of fetoplacental vascular tree

Objective: The placental vascular architecture of small-for-gestatonal-age fetuses seems to have an impact on the flow patterns in the umbilical arteries. Study Design: Blood flow velocity waveforms of the umbilical arteries were measured by Doppler ultrasonography in nine small-for-gestational-age fetuses with elevated systolic/diastolic ratios of the umbilical arteries, seven small-for-gestational-age fetuses with normal flow patterns, and 14 appropriate-for-gestational-age fetuses with normal flow patterns. After delivery histomorphometric placental investigations were performed. Results: Reduced end-diastolic flow velocities were significantly associated with both a reduction of vascula…

86P Patients (pts) preference for different administration methods of trastuzumab (T) in pts with HER2+ early breast cancer (BC) treated within the GAIN-2 trial

Isolation and characterization of maerophage-derived C1q and its similarities to serum C1q

Recently, we have shown that the collagen-like, Fc-recognizing subcomponent C1q of the first complement component is synthesized by human, guinea pig and mouse peritoneal macrophages. To test whether macrophages may contribute to the serum pool of C1q, C1q was purified from guinea pig serum and from guinea pig peritoneal macrophage supernatants and compared for similarities. Both molecules had a similar sedimentation rate (macrophage C1q: 11.3 S, serum C1q: 11.2 S) and showed on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions three identical bands with molecular weights of Mr, 29 000, Mr, 27 000 and Mr 23 000 for the A, B and C chains, respectively. Both …

The reconstitution of human C1, the first complement component Binding of C1r and C1s to C1q influences the C1q conformation