0000000000049746

AUTHOR

Hütteroth Th

showing 5 related works from this author

Humoral immune reactions on the hepatocellular plasma membrane in the experimental chronic active hepatitis in rabbits

1976

Zur Induktion einer experimentellen chronisch aktiven Hepatitis (CAH) wurden Kaninchen mit humanem leberspezifischem Protein plus komplettem Freundschen Adjuvans langzeitimmunisiert. Nach 23wochiger Versuchsdauer waren im Serum Antikorper gegen allogene hepatocellulare Membranantigene mit Hilfe isolierter normaler Kaninchenhepatocyten bzw. in der passiven Hamagglutination mit leberspezifischem Membranprotein als Antigen nachweisbar. Gleichzeitig zeigten isolierte Hepatocyten dieser Tiere in vivo-fixiertes IgG an den Plasmamembranen in Form eines gemischt linear-granularen Fluoreszenzmusters. Mit der Raji-Zell-Technik wurden im Serum der Tiere Immunkomplexe gefunden. Eine chronisch aktive He…

Hepatitisbusiness.industryDrug DiscoveryMolecular MedicineMedicineGeneral MedicineImmune reactionbusinessmedicine.diseaseMolecular biologyGenetics (clinical)Klinische Wochenschrift
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A case of sjögren's syndrome with severe anemia due to myelitis

1986

An unusual case of Sjögren's syndrome presenting with severe anemia as the predominant clinical feature is described. Histological examination of a bone marrow biopsy specimen demonstrated that the patient's anemia was caused by myelitis and vasculitis of the small intraosseous vessels. Our report might stimulate a more thorough investigation of bone marrow in patients with connective tissue diseases and anemia.

MalePathologymedicine.medical_specialtyAnemiaConnective tissueMyelitisSevere anemiaBone Marrowhemic and lymphatic diseasesDrug DiscoveryBiopsymedicineHumansGenetics (clinical)medicine.diagnostic_testbusiness.industryAnemiaOsteomyelitisArteriesGeneral MedicineMiddle AgedHematopoietic Stem Cellsmedicine.diseasePolyarteritis NodosaSjogren's Syndromemedicine.anatomical_structureMolecular MedicineBone marrowSjogren sbusinessVasculitisKlinische Wochenschrift
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Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und A…

1976

Eine Analyse der Literatur und eigene Befunde uber die Haufigkeit von 23 HLA-Antigenen bei Patienten mit Hepatitis-Oberflachen-Antigen (HBsAg)-positiver und -negativer chronisch aktiver Hepatitis (CAH) und gesunden Tragern von HBsAg und Antikorpern gegen HBsAg (Anti-HBs) erlauben die folgenden Schlusfolgerungen: 1. Bei Patienten mit CAH und HBsAg-Persistenz findet sich eine normale Haufigkeit von HLA-B8 (und -A1). 2. Auch bei Patienten mit HBsAg-negativen Formen einer CAH ohne Autoimmunphanomene (AutoAk) ist die HLA-B8-Haufigkeit normal. 3. Nur Patienten mit HBsAg-negativer CAH mit AutoAk haben eine statistisch signifikant grosere Haufigkeit von HLA-B8 (und -A1) (p < 0,01 nach Korrektion fu…

GynecologyAnti hbsmedicine.medical_specialtyHBsAgbusiness.industryDrug Discoverymedicinevirus diseasesMolecular MedicineGeneral Medicinebusinessdigestive system diseasesGenetics (clinical)Klinische Wochenschrift
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The effect of recombinant alpha-interferon treatment on serum levels of hepatitis B virus-encoded proteins in man.

1987

The effect of alpha-interferon treatment on serum levels of hepatitis B virus-encoded proteins was analyzed in eight patients with chronic type B hepatitis who participated in a pilot study of interferon therapy. Three individuals became HBsAg-negative, 4 lost HBeAg but remained HBsAg-positive and 1 remained positive for both HBsAg and HBeAg. Initiation of interferon treatment was rapidly followed by reduction or loss of hepatitis B virus DNA in the serum but by little immediate change in hepatitis B virus antigen levels. Changes in hepatitis B virus antigens were usually delayed. Loss of HBsAg from the serum was preceded by the sequential disappearance of pre-S-encoded proteins (pre-S1 and…

AdultMaleHBsAgGenes ViralvirusesAlpha interferonmedicine.disease_causeHepatitis B AntigensViral ProteinsInterferonmedicineHumansHepatitis B e AntigensHepatitis ChronicHepatitis B virusHepatitisHepatitis B Surface AntigensHepatologybusiness.industryvirus diseasesHepatitis BMiddle Agedmedicine.diseaseHuman serum albuminVirologydigestive system diseasesRecombinant ProteinsHBeAgImmunologyDNA ViralInterferon Type IFemalebusinessmedicine.drugHepatology (Baltimore, Md.)
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Hepatitis A-like non-A, non-B hepatitis: light and electron microscopic observations of three cases.

1986

To date, three types of NANBH have been distinguished by epidemiological, clinical and experimental data. We examined the liver biopsies of three patients with an acute NANBH resembling hepatitis A from the infection route, incubation period and clinical course. The liver biopsies revealed lesions with a portal and periportal predominance, thus also exhibiting parallels with hepatitis A on the histopathological level.

AdultMalePathologymedicine.medical_specialtyHepatitis Viral HumanBiologyPathology and Forensic MedicineIncubation periodHLA AntigensPregnancymedicineHumansMolecular BiologyElectron microscopicClinical courseHistocompatibility Antigens Class IIHepatitis ACell BiologyGeneral MedicineHLA-DR AntigensHepatitis AMiddle Agedmedicine.diseaseMicroscopy ElectronImmunologic TechniquesNon b hepatitisFemaleViral diseaseVirchows Archiv. A, Pathological anatomy and histopathology
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