0000000000051538

AUTHOR

Liana Pliss

showing 4 related works from this author

Mitochondrial DNA Portrait of Latvians: Towards the Understanding of the Genetic Structure of Baltic-Speaking Populations

2005

Summary Mitochondrial DNA (mtDNA) variation was investigated in a sample of 299 Latvians, a Baltic-speaking population from Eastern Europe. Sequencing of the first hypervariable segment (HVS-I) in combination with analysis of informative coding region markers revealed that the vast majority of observed mtDNAs belong to haplogroups (hgs) common to most European populations. Analysis of the spatial distribution of mtDNA haplotypes found in Latvians, as well as in Baltic-speaking populations in general, revealed that they share haplotypes with all neighbouring populations irrespective of their linguistic affiliation. Hence, the results of our mtDNA analysis show that the previously described s…

Baltic StatesMaleMitochondrial DNAGenetic LinkagePopulationPopulation geneticsBiologyDNA MitochondrialWhite PeopleHaplogroupOpen Reading FramesGeneticsHumansCoding regioneducationPhylogenyGenetics (clinical)LanguageGeneticseducation.field_of_studyChromosomes Human YHaplotypeGenetic VariationComplementarity Determining RegionsLatviahumanitiesGenetics PopulationHaplotypesGenetic structureFemaleGene poolAnnals of Human Genetics
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Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population

2014

Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geographic location, and/or specific historic background. The aims of this study were to identify a specific hg which correlates with aging in a Latvian populating and to evaluate the possible association of TL variability with specific mitochondrial hgs. The results show no significant correlation between TL, mitochondrial DNA hgs and longevity. A slight increase in frequency was obse…

AdultMaleAgingMitochondrial DNAmedia_common.quotation_subjectLongevityPopulationBiologyDNA MitochondrialHaplogroupTelomere HomeostasisHumanseducationAgedmedia_commonAged 80 and overGeneticseducation.field_of_studyHaplotypeLongevityTelomere HomeostasisMiddle AgedTelomereLatviaTelomereHaplotypesFemaleDevelopmental BiologyHuman mitochondrial DNA haplogroupMechanisms of Ageing and Development
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The link between mitochondrial DNA hypervariable segment I heteroplasmy and ageing among genetically unrelated Latvians

2011

International audience; Various studies have demonstrated that mitochondrial DNA (mtDNA) heteroplasmy tends to increase with age and that the observed frequency of heteroplasmy among populations mostly depends on the way it is measured. Therefore, we investigated age-related association on the presence of mtDNA heteroplasmy within the hypervariable segment 1 (HVS-I) in a selected study group. The study group consisted of 300 maternally unrelated Latvians ranging in age from 18 to over 90years. To determine the optimal method for mtDNA heteroplasmy detection, three approaches were used: (i) SURVEYORTM Mutation Detection Kit, (ii) sequencing and (iii) denaturing gradient-gel electrophoresis (…

AdultMaleMitochondrial DNAAgingAdolescentBiologyBiochemistryDNA MitochondrialBroad spectrumYoung AdultEndocrinologyLatviansGeneticsHumansMutation detectionheteroplasmydetection of mtDNA heteroplasmyMolecular BiologyAgedGeneticsAged 80 and overDenaturing Gradient Gel ElectrophoresismtDNA[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontologyCell BiologySequence Analysis DNAMiddle AgedLatviaHeteroplasmyAgeingageingMutationFemaleHuman mitochondrial DNA haplogroup
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Promocijas darbs

2007

Elektroniskā versija nesatur pielikumus

Dzīvās dabas zinātnesBioloģija
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