0000000000051924

AUTHOR

Rudolf A. Jörres

showing 5 related works from this author

CAT score single item analysis in patients with COPD: results from COSYCONET

2019

Abstract The COPD Assessment Test (CAT) is in widespread use for the evaluation of patients with chronic obstructive pulmonary disease (COPD). We assessed whether the CAT items carry additional information beyond the sum score regarding COPD characteristics including emphysema. Patients of GOLD grades 1 to 4 from the COPD cohort COSYCONET (German COPD and Systemic Consequences - Comorbidities Network) with complete CAT data were included (n = 2270), of whom 493 had chest CT evaluated for the presence of emphysema. Comorbidities and lung function were assessed following standardised procedures. Cross-sectional data analysis was based on multiple regression analysis of the single CAT items ag…

Pulmonary and Respiratory MedicinePercentilemedicine.medical_specialtyMedizinDiagnostic Techniques Respiratory System610Single itemCAT score03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicineCOPDIn patient030212 general & internal medicineLung functionEmphysemaCOPDbusiness.industryRegression analysisCat Score ; Copd ; Emphysemamedicine.diseaseExploratory factor analysisrespiratory tract diseases030228 respiratory systemCohortbusiness61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V.
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The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline

2016

Abstract Background The German COPD cohort study COSYCONET (" CO PD and SY stemic consequences- CO morbidities NET work") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort. Methods Inclusion criteria were broad in order to cover a wide range of patterns of the disease. In each visit, patients undergo a large panel …

SpirometryAdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyComorbiditySeverity of Illness IndexCohort Studies03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsInternal medicineGermanySeverity of illnessMedicineHumansCOPD030212 general & internal medicineProspective StudiesProspective cohort studyAgedAged 80 and overCOPDmedicine.diagnostic_testSystemic inflammationbusiness.industrySmokingCohortStudy designMiddle Agedmedicine.diseaseComorbiditySystemic Inflammatory Response SyndromeObservational Studies as Topic030228 respiratory systemCohortPhysical therapyDisease ProgressionPopulation studyFemaleCohort ; Comorbidity ; Copd ; Study Design ; Systemic InflammationbusinessCohort studyFollow-Up StudiesRespiratory Medicine
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Telomere Length in Circulating Leukocytes is Associated with Lung Function and Disease

2014

Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and s…

Lung DiseasesMalePulmonary and Respiratory MedicineSpirometryNetherlands Twin Register (NTR)Vital capacityVital Capacityennenaikainen vanheneminenDiseaseCohort StudiesPathogenesisPulmonary Disease Chronic ObstructiveTelomere HomeostasisSDG 3 - Good Health and Well-beingForced Expiratory VolumeastmaLeukocytes/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCOPDMedicinekeuhkoahtaumatautiAgedAsthmatelomeeriCOPDmedicine.diagnostic_testpremature agingbusiness.industrySmokingCase-control studyta3141Middle AgedTelomerespirometriamedicine.diseaseAsthmabiologinen ikäbiological age3. Good healthrespiratory tract diseasesEuropeSpirometryCase-Control StudiesImmunologyRegression Analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalebusinessEuropean Respiratory Journal
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Use of a portable device to record maximum inspiratory flow in relation to dyspnoea in patients with COPD

2011

SummaryForced inspiratory measures have been described to reflect the reduction in dyspnoea upon bronchodilation in severe COPD. Based on this we evaluated the applicability and usefulness of a portable device for the assessment of forced inspiration. In 37 patients with COPD (GOLD II/II/IV n = 16/15/6, mean ± SD FEV1 46.2 ± 15.4%pred) lung function was recorded prior to inhalation of 24 μg formoterol and 30 min later. Assessments comprised spirometry including forced inspiration, body plethysmography, maximum inspiratory flow (InCheck, Clement Clarke), and changes in dyspnoea via visual analogue scale (VAS). The sequence was repeated on a second day to assess reproducibility. Bronchodilati…

MalePulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyPortable deviceVisual analogue scalePeak inspiratory flowPulmonary Disease Chronic ObstructiveForced inspirationInternal medicineDyspnoeaBronchodilationCOPDHumansMedicinePlethysmographPeak flow meterMonitoring Physiologicmeasurement_unitAnalysis of VarianceCOPDmedicine.diagnostic_testbusiness.industrymedicine.diseaserespiratory tract diseasesBronchodilatationDyspneaSpirometrymeasurement_unit.measuring_instrumentPhysical therapyCardiologyBronchodilationFemaleFormoterolbusinessInspiratory Capacitymedicine.drugRespiratory Medicine
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Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET.

2020

Bronchiectasis (BE) might be frequently present in COPD but masked by COPD symptoms. We studied the relationship of clinical signs of bronchiectasis to the presence and extent of its radiological signs in patients of different COPD severity. Visit 4 data (GOLD grades 1-4) of the COSYCONET cohort was used. Chest CT scans were evaluated for bronchiectasis in 6 lobes using a 3-point scale (0: absence, 1: ≤50%, 2: >50% BE-involvement for each lobe). 1176 patients were included (61%male, age 67.3y), among them 38 (3.2%) with reported physicians' diagnosis of bronchiectasis and 76 (6.5%) with alpha1-antitrypsin deficiency (AA1D). CT scans were obtained in 429 patients. Within this group, any sign…

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyCopd patientsMedizinComorbiditySeverity of Illness IndexPulmonary Disease Chronic ObstructiveMedicineHumansIn patientLungAgedAged 80 and overCOPDBronchiectasisbusiness.industryPhlegmMiddle Agedmedicine.diseaseBronchiectasisRadiological weaponClinical diagnosisCohortFemaleRadiography ThoracicRadiologymedicine.symptombusinessTomography X-Ray ComputedRespiratory medicine
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