6533b7cefe1ef96bd1257a49

RESEARCH PRODUCT

CAT score single item analysis in patients with COPD: results from COSYCONET

J. Randerath WinfriedPfeifer MichaelKenn KlausJoachim H. FickerGogol ManfredGrohé ChristianHöffken GerdZaklina HinzJulia TobiasHenke MarkusTeschler HelmutWelte TobiasBenjamin WaschkiBuhl RolandPaul W. JonesKirsten Anne-marieA. Katus HugoTaube ChristianBewig BurkhardBeate PolteKronsbein JulianeStubbe BeateBals RobertJohanna I. LutterSarah Marietta Von SiemensLange ChristophVogelmeier ClausEllen BurmannWirtz HubertKathrin KahnertErich TraugottBehr JürgenBirte StruckVivien JankeLenka KrabbeTimmermann HartmutWagner UlrichAnita ReichelSabine MichalewskiGudrun HübnerSeeger WernerDoris LehnertJany BertholdKropf-sanchen CorneliaSandra SöhlerJeanette PieperUlrike RieberPeter AlterHerth FelixZabel PeterAndreas StefanKoczulla RembertHeld MatthiasTobias WelteFranziska C. TrudzinskiPatricia BergerKahnert KathrinJana GrafJürgen BehrRosalie UntschRudolf A. JörresKornelia SpethBritta MarkworthEwert RalfGertraud WeißHans-ulrich KauczorClaus VogelmeierKatrin SchwedlerKatrin WonsBertram J. JobstBarbara ArikanMargret GleinigerHenrik WatzWatz HenrikStudnicka MichaelBeate SchauflerDiana SchottelSonja RohwederRobert BalsIlona KietzmannVirchow J. ChristianBurkhard BewigHauck RainerMichaela Schrade-illmann

subject

Pulmonary and Respiratory MedicinePercentilemedicine.medical_specialtyMedizinDiagnostic Techniques Respiratory System610Single itemCAT score03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicineCOPDIn patient030212 general & internal medicineLung functionEmphysemaCOPDbusiness.industryRegression analysisCat Score ; Copd ; Emphysemamedicine.diseaseExploratory factor analysisrespiratory tract diseases030228 respiratory systemCohortbusiness

description

Abstract The COPD Assessment Test (CAT) is in widespread use for the evaluation of patients with chronic obstructive pulmonary disease (COPD). We assessed whether the CAT items carry additional information beyond the sum score regarding COPD characteristics including emphysema. Patients of GOLD grades 1 to 4 from the COPD cohort COSYCONET (German COPD and Systemic Consequences - Comorbidities Network) with complete CAT data were included (n = 2270), of whom 493 had chest CT evaluated for the presence of emphysema. Comorbidities and lung function were assessed following standardised procedures. Cross-sectional data analysis was based on multiple regression analysis of the single CAT items against a panel of comorbidities, lung function, or CT characteristics (qualitative score, 15th percentile of mean lung density), with age, BMI and gender as covariates. This was supported by exploratory factor analysis. Regarding the relationship to comorbidities and emphysema, there were marked differences between CAT items, especially items 1 and 2 versus 3 to 8. This grouping was basically confirmed by factor analysis. Items 4 and 5, and to a lower degree 1, 2 and 6, appeared to be informative regarding the presence of emphysema, whereas the total score was not or less informative. Regarding comorbidities, similar findings as for the total CAT score were obtained for the modified Medical Research Council scale (mMRC) which was also informative regarding emphysema. Our findings suggest that the usefulness of the CAT can be increased if evaluated on the basis of single items which may be indicating the presence of comorbidities and emphysema.

yearjournalcountryeditionlanguage
2019-01-0161. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V.
https://doi.org/10.1055/s-0039-3403209