0000000000053058

AUTHOR

Giuseppe Barbagallo Sangiorgi

showing 3 related works from this author

The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2.

1992

Abstract It is well known that the function of T lymphocytes is significantly impaired by advancing age. In the present study, attempts have been made to further characterize the T cell impairment of elderly subjects. Thus, we have performed limiting dilution microculture analysis to evaluate the precursor frequency of T lymphocytes responding to a mitogenic stimulus in old and young subjects. Furthermore we have evaluated the activity of recombinant interleukin-2 (rIL-2) on these cells. The results demonstrate that in older subjects the frequency of these precursors is significantly decreased. The in vitro treatment with rIL-2 increased the frequency of mitogen responsive T lymphocyte prec…

Interleukin 2AdultMalemedicine.medical_specialtyAgingmedicine.medical_treatmentT cellT-LymphocytesIn Vitro TechniquesLymphocyte ActivationInternal medicinemedicineConcanavalin AHumansAgedAged 80 and overbiologyCell growthT lymphocyteMiddle AgedHematopoietic Stem CellsIn vitroEndocrinologyCytokinemedicine.anatomical_structureConcanavalin AAgeingImmunologybiology.proteinInterleukin-2FemaleDevelopmental Biologymedicine.drugMechanisms of ageing and development
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Morphea after silicone gel breast implantation for cosmetic reasons in an HLA-B8,DR3-positive woman

1997

We describe an HLA-B8, DR3-positive patient with localized morphea after silicone gel breast implantation for cosmetic reasons. We believe that this case suggests that a genetic background, i.e. HLA-B8, DR3 haplotype, is involved in the autoimmune response to silicone.

Adultmusculoskeletal diseasesmedicine.medical_specialtyBreast implantationBreast ImplantsMammaplastyImmunologyMammary glandCD4-CD8 RatioSiliconesHLA-B8 AntigenScleroderma Localizedchemistry.chemical_compoundHLA-DR3 AntigenSiliconeLocalized morpheamedicineHumansImmunology and AllergySurgery Plasticskin and connective tissue diseasesGlucocorticoidsbusiness.industrytechnology industry and agricultureGeneral Medicinemedicine.diseaseConnective tissue diseaseSurgeryPlastic surgerymedicine.anatomical_structurechemistryImmunologyPrednisoneFemalebusinessMorpheaCircumscribed scleroderma
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alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial.

1994

The clinical efficacy and the tolerability of alpha-glycerophosphocholine (alpha-GPC), a drug able to provide high levels of choline for the nervous cells of the brain and to protect their cell walls, have been tested in a clinical open multicenter trial on 2044 patients suffering from recent stroke or transient ischemic attacks. alpha-GPC was administered after the attack at the daily dose of 1000 mg im for 28 days and orally at the dose of 400 mg tid during the following 5 months after the first phase. The evaluation of the efficacy on the psychic recovery was done by the Mathew Scale (MS) during the period of im drug administration, and using the Mini Mental State Test (MMST), the Cricht…

MaleGeneral Biochemistry Genetics and Molecular BiologyBrain IschemiaHistory and Philosophy of ScienceRating scaleOral administrationMulticenter trialmedicineHumansCognitive declineAdverse effectStrokeAgedAged 80 and overbusiness.industryGeneral NeuroscienceDementia VascularHeartburnMiddle Agedmedicine.diseaseGlycerylphosphorylcholineTolerabilityAnesthesiaFemalemedicine.symptombusinessAnnals of the New York Academy of Sciences
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