showing 3 related works from this author
ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker.
2019
Abstract Alzheimer’s disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) cleavage, which can be processed by two pathways. The cleavage by the α-secretase A Disintegrin And Metalloprotease 10 (ADAM10) releases the soluble portion (sAβPPα) and prevents senile plaques. This pathway remains largely unknown and ignored, mainly regarding pharmacological approaches that may act via different signaling cascades and thus stimulate non-amyloidogenic cleavage through ADAM10. This review emphasizes the effects of natural compounds on ADAM10 modulation, which eventuates in a neuroprotective mechanism. M…
Is device-measured vigorous physical activity associated with health-related outcomes in children and adolescents? A systematic review and meta-analy…
2021
Highlights • Higher vigorous-intensity physical activity seems to be negatively related to adiposity and cardiometabolic risk score among children and adolescents later in life. • Higher vigorous-intensity physical activity is positively related to cardiorespiratory fitness and total body bone mineral density among children and adolescents later in life. • The present results support the need to further strengthen vigorous-intensity physical activity recommendations for children and adolescents.
Is adherence to the Mediterranean diet associated with healthy habits and physical fitness? A systematic review and meta-analysis including 565 421 y…
2020
AbstractThe relationship between adherence to the Mediterranean diet (MD), physical activity (PA), sedentary behaviour and physical fitness levels has been analysed in several studies; however, there is mixed evidence among youth. Thus, this study aimed to meta-analyse the associations between adherence to the MD, PA, sedentary behaviour and physical fitness among children and adolescents. Three databases were systematically searched, including cross-sectional and prospective designs with a sample of healthy youth aged 3–18 years. Random effects inverse-variance model with the Hartung–Knapp–Sidik–Jonkman adjustment was used to estimate the pooled effect size (correlation coefficient (r)). T…