0000000000054290

AUTHOR

Irene Del Canto

showing 6 related works from this author

Evaluation of the Complexity of Myocardial Activation During Ventricular Fibrillation. An Experimental Study

2013

A B S T R A C T Introduction and objectives: An experimental model is used to analyze the characteristics of ventricular fibrillation in situations of variable complexity, establishing relationships among the data produced by different methods for analyzing the arrhythmia. Methods: In 27 isolated rabbit heart preparations studied under the action of drugs (propranolol and KB-R7943) or physical procedures (stretching) that produce different degrees of change in the complexity of myocardial activation during ventricular fibrillation, use was made of spectral, morphological, and mapping techniques to process the recordings obtained with epicardial multielectrodes. Results: The complexity of ve…

medicine.medical_specialtyMultivariate analysisCoefficient of variationmedia_common.quotation_subjectComplexity indexsymbols.namesakeInternal medicinemedicineAnimalsmedia_commonVariablesbusiness.industrySpectral densityHeartGeneral Medicinemedicine.diseaseFourier analysisVentricular FibrillationVentricular fibrillationCardiologysymbolsRabbitsElectrophysiologic Techniques CardiacbusinessBiological systemEnergy (signal processing)Revista Española de Cardiología (English Edition)
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Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits

2020

Simple Summary Ischemic heart disease is one of the leading causes of death. A series of processes occur during acute myocardial infarction that contribute to the development of ventricular dysfunction, with subsequent heart failure and ventricular arrhythmias, which account for most episodes of sudden cardiac death in these patients. These complications are associated with the adverse cardiac remodeling that occurs during the healing process following an acute episode. The remodeling causes the appearance of a substrate that can trigger life-threatening arrhythmias, such as tachycardia and/or ventricular fibrillation. The development of experimental models for analyzing the basic mechanism…

Programmed stimulationmedicine.medical_specialtyLong term follow upmedicine.medical_treatment030204 cardiovascular system & hematologyischemia/reperfusion injuryventricular remodelingArticle03 medical and health sciencesexperimental surgery0302 clinical medicineRisk areaInternal medicinelcsh:ZoologymedicineMyocardial infarctionlcsh:QL1-991cardiovascular diseasesVentricular remodelingLigature030304 developmental biology0303 health scienceslcsh:Veterinary medicineGeneral Veterinarybusiness.industryExperimental modelventricular arrhythmiasInfarct sizemedicine.diseasemyocardial infarctionCardiologycardiovascular systemlcsh:SF600-1100Animal Science and Zoologycardiac mappingbusinessAnimals : an Open Access Journal from MDPI
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Effect of chronic exercise on myocardial electrophysiological heterogeneity and stability. Role of intrinsic cholinergic neurons: A study in the isol…

2018

[EN] A study has been made of the effect of chronic exercise on myocardial electrophysiological heterogeneity and stability, as well as of the role of cholinergic neurons in these changes. Determinations in hearts from untrained and trained rabbits on a treadmill were performed. The hearts were isolated and perfused. A pacing electrode and a recording multielectrode were located in the left ventricle. The parameters determined during induced VF, before and after atropine (1 mu M), were: fibrillatory cycle length (VV), ventricular functional refractory period (FRPVF), normalized energy (NE) of the fibrillatory signal and its coefficient of variation (CV), and electrical ventricular activatio…

0301 basic medicineAtropineMaleRefractory Period ElectrophysiologicalRefractory periodPhysiology030204 cardiovascular system & hematologyBiochemistryRunningTissue Culture Techniques0302 clinical medicineAnimal CellsMuscarinic acetylcholine receptorMedicine and Health SciencesMedicinePublic and Occupational HealthTreadmillMammalsNeuronsMultidisciplinaryQREukaryotaHeartNeurochemistryNeurotransmittersAnimal ModelsSports ScienceCardiovascular physiologyElectrophysiologyAtropineChemistrymedicine.anatomical_structureExperimental Organism SystemsVentricular FibrillationPhysical SciencesVertebratesCardiologyLeporidsMedicineRabbitsCellular TypesAnatomyArrhythmiamedicine.drugResearch Articlemedicine.medical_specialtyScienceCholinergicsCardiologyMuscarinic AntagonistsResearch and Analysis MethodsTECNOLOGIA ELECTRONICA03 medical and health sciencesAlkaloidsInternal medicineAnimalsCholinergic neuronSports and Exercise MedicineExercisebusiness.industryChemical CompoundsOrganismsParasympatholyticsBiology and Life SciencesCell BiologyPhysical ActivityElectrophysiology030104 developmental biologyVentriclePhysical FitnessCellular NeuroscienceAmniotesAnimal StudiesCardiovascular AnatomybusinessNeuroscience
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Estudio experimental de los efectos de EIPA, losartán y BQ-123 sobre las modificaciones electrofisiológicas inducidas por el estiramiento miocárdico

2015

Resumen Introduccion y objetivos Se han implicado diversos mecanismos en la respuesta mecanica al estiramiento miocardico, que incluyen la activacion del intercambiador Na+/H+ por acciones autocrinas y paracrinas. Se estudia la participacion de estos mecanismos en las respuestas electrofisiologicas al estiramiento agudo miocardico mediante el analisis de los cambios inducidos con farmacos. Metodos Se analizan las modificaciones de la fibrilacion ventricular inducidas por el estiramiento agudo miocardico en corazones de conejo aislados y perfundidos utilizando electrodos multiples epicardicos y tecnicas cartograficas. Se estudian 4 series: control (n = 9); durante la perfusion del antagonist…

business.industryMedicineCardiology and Cardiovascular MedicinebusinessHumanitiesRevista Española de Cardiología
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Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch

2015

[ES] Introducción y objetivos Se han implicado diversos mecanismos en la respuesta mecánica al estiramiento miocárdico, que incluyen la activación del intercambiador Na+/H+ por acciones autocrinas y paracrinas. Se estudia la participación de estos mecanismos en las respuestas electrofisiológicas al estiramiento agudo miocárdico mediante el análisis de los cambios inducidos con fármacos. Métodos Se analizan las modificaciones de la fibrilación ventricular inducidas por el estiramiento agudo miocárdico en corazones de conejo aislados y perfundidos utilizando electrodos múltiples epicárdicos y técnicas cartográficas. Se estudian 4 series: control (n = 9); durante la perfusión del antagonista d…

Endothelin Receptor AntagonistsAngiotensin receptorINGENIERIA MECANICAArritmiaAngiotensin II receptor antagonistPharmacologyAmiloridechemistry.chemical_compoundReceptorBiomechanical stressMapeoDrugsHeartGeneral MedicineElectrophysiologyLosartanMappingFármacosCardiologyRabbitsmedicine.symptomEndothelin receptorPerfusionArrhythmiamedicine.drugmedicine.medical_specialtySodium-Hydrogen ExchangersPeptides CyclicLosartanEndothelinElectrofisiologíaTECNOLOGIA ELECTRONICAEndotelinaStress PhysiologicalInternal medicinemedicineEpithelial Sodium Channel BlockersAnimalsVentricular fibrillationFibrilación ventricularFibrillationBQ-123Investigación básicabusiness.industryMyocardiumInhibidores de la angiotensinachemistryAngiotensin inhibitorsMiocardioEstrés biomecánicombusinessBasic researchAngiotensin II Type 1 Receptor Blockers
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Evaluación de la complejidad de la activación miocárdica durante la fibrilación ventricular. Estudio experimental

2013

Resumen Introduccion y objetivos Analizar en un modelo experimental las caracteristicas de la fibrilacion ventricular en situaciones con distintos grados de complejidad y establecer la relacion existente entre los datos aportados por distintos metodos de analisis de la arritmia. Metodos En 27 preparaciones de corazon aislado de conejo estudiadas bajo la accion de farmacos (propranolol y KB-R7943) o procedimientos fisicos (estiramiento) que causan distintos grados de variacion de la complejidad de la activacion miocardica durante la arritmia, se han utilizado tecnicas espectrales, morfologicas y cartograficas para procesar los registros obtenidos con multielectrodos epicardicos. Resultados L…

business.industryMedicineCardiology and Cardiovascular MedicinebusinessHumanitiesRevista Española de Cardiología
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