0000000000056047

AUTHOR

Carmela Picone

showing 3 related works from this author

An Analysis of the Immunomodulatory Properties of Human Spheroids from Adipose-Derived Stem Cells

2023

Aims Current methods to induce tolerance following allotransplantation or in autoimmunity carry significant morbidity, and research is very active in investigating alternative methods which could minimize toxicity. Spheroids from adipose stem cells (SASCs) are increasingly gaining interest, they hold a great proliferative and differentiating potential. An immunomodulatory effect has not been investigated on SASCs yet. In this study, we analysed the immunomodulatory properties of SASCs and compared them to ADSCs. Main methods Adipose stem cells (SASCs and ADSCs) and peripheral blood mononuclear cells (PBMCs) were collected from healthy individuals. We analysed the cytokine production and pro…

HistoryPolymers and PlasticsGeneral MedicineGeneral Pharmacology Toxicology and PharmaceuticsBusiness and International ManagementImmunosuppression Adipose tissue Spheroids of adipose stem cell Cell therapyGeneral Biochemistry Genetics and Molecular BiologyIndustrial and Manufacturing EngineeringSSRN Electronic Journal
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Phenotypical and Functional Alteration of γδ T Lymphocytes in COVID-19 Patients: Reversal by Statins

2022

(1) Background: statins have been considered an attractive class of drugs in the pharmacological setting of COVID-19 due to their pleiotropic properties and their use correlates with decreased mortality in hospitalized COVID-19 patients. Furthermore, it is well known that statins, which block the mevalonate pathway, affect γδ T lymphocyte activation. As γδ T cells participate in the inflammatory process of COVID-19, we have investigated the therapeutical potential of statins as a tool to inhibit γδ T cell pro-inflammatory activities; (2) Methods: we harvested peripheral blood mononuclear cells (PBMCs) from COVID-19 patients with mild clinical manifestatio…

T-Lymphocyte SubsetsSARS-CoV-2 infectionLeukocytes Mononuclearmevalonate pathwaystatinHumansCOVID-19γδ T cells; COVID-19; SARS-CoV-2 infection; statin; mevalonate pathwayReceptors Antigen T-Cell gamma-deltaGeneral MedicineHydroxymethylglutaryl-CoA Reductase Inhibitorsγδ T cellsCOVID-19 Drug TreatmentCells; Volume 11; Issue 21; Pages: 3449
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Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

2021

The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…

tumoral metabolismQH301-705.5T-LymphocytesPopulationReviewMajor histocompatibility complexγδ T cellsImmune systemAntigens NeoplasmIn vivomedicineAnimalsHumanstumor microenvironmentBiology (General)educationtumoral metabolism; ?? T cells; tumor microenvironmentClinical Trials as Topiceducation.field_of_studyTumor microenvironmentbiologyReceptors Antigen T-Cell gamma-deltaBiological activityGeneral MedicineHypoxia (medical)Lipid MetabolismIn vitroCell biologybiology.proteinmedicine.symptom
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