0000000000056187
AUTHOR
Markus Peter Fickinger
Primary enduring negative symptoms in schizophrenia and major depression.
Abstract Primary enduring negative symptoms (PENS) were studied in 26 patients with DSM-III-R schizophrenia and in 94 patients with unipolar major depressive episodes 5 years after the index episode. PENS were assessed with the Schedule for Deficit Syndrome (SDS). Negative symptoms were also assessed with the Scale for Assessment of Negative Symptoms (SANS) and subclassified into primary and secondary according to the SDS. The frequency of PENS did not differ significantly between schizophrenics and non-schizophrenic patients. Enduring negative symptoms (regardless of whether primary or not) were more frequently observed in schizophrenia (65% according to the SDS, and 88% according to the S…
Bestimmt die Episodenzahl den Ausgang unipolarer Depressionen?
Bei affektiven Psychosen wissen wir noch nicht ausreichend, wie eng die verschiedenen Parameter des Verlaufs und des Ausgangs miteinander korreliert sind. Eine wichtige, bisher nicht geklarte Frage ist, ob die psychosoziale Anpassung bei unipolaren Depressionen von einem phasenhaften Krankheitsverlauf abhangig ist. Ziel unserer Untersuchung war es, zu prufen, ob Patienten mit der Erstmanifestation einer Major Depression funf Jahre nach Indexuntersuchung eine bessere psychosoziale Anpassung erreichen als Patienten mit fruheren Episoden.
Comparison of Paroxetine and Maprotiline in Minor Depression
Whilst the efficacy of paroxetine has been demonstrated in MDD, its clinical utility in minor depression has not been established. This study assesses the antidepressant efficacy of paroxetine in patients meeting RDC criteria for minor depression. All patients scored 13 points on the 17-item Hamilton Depression Rating Scale (HAMD) at baseline. After a 3 day washout period, patients were randomised to receive paroxetine 20–40mg/day or maprotiline 100-150mg/day, dose being titrated according to clinical response after 3 weeks treatment at the lower doses. Assessments conducted at baseline (day 0) and at weekly intervals for 6 weeks included the 17-item HAMD, the Montgomery-Asberg Depression R…