Phenol compounds as new materials for electron spin resonance dosimetry in radiotherapy

Testing and linearity calibration of films of phenol compounds exposed to thermal neutron field for EPR dosimetry

This paper reports the preliminary results obtained by Electron Paramagnetic Resonance (EPR) measurements on films of IRGANOX® 1076 phenols with and without low content (5% by weight) of gadolinium oxide (Gd2O3) exposed in the thermal column of the Triga Mark II reactor of LENA (Laboratorio Energia Nucleare Applicata) of Pavia (Italy). Thanks to their size, the phenolic films here presented are good devices for the dosimetry of beams with high dose gradient and which require accurate knowledge of the precise dose delivered. The dependence of EPR signal as function of neutron dose was investigated in the fluence range between 10(11) cm(-2) and 10(14) cm(-2). Linearity of EPR response was fou…

Neutron flux and gamma dose measurement in the BNCT irradiation facility at the TRIGA reactor of the University of Pavia

Abstract University of Pavia is equipped with a TRIGA Mark II research nuclear reactor, operating at a maximum steady state power of 250 kW. It has been used for many years to support Boron Neutron Capture Therapy (BNCT) research. An irradiation facility was constructed inside the thermal column of the reactor to produce a sufficient thermal neutron flux with low epithermal and fast neutron components, and low gamma dose. In this irradiation position, the liver of two patients affected by hepatic metastases from colon carcinoma were irradiated after borated drug administration. The facility is currently used for cell cultures and small animal irradiation. Measurements campaigns have been ca…

Accelerated Tests on Si and SiC Power Transistors with Thermal, Fast and Ultra-Fast Neutrons

Neutron test campaigns on silicon (Si) and silicon carbide (SiC) power MOSFETs and IGBTs were conducted at the TRIGA (Training, Research, Isotopes, General Atomics) Mark II (Pavia, Italy) nuclear reactor and ChipIr-ISIS Neutron and Muon Source (Didcot, U.K.) facility. About 2000 power transistors made by STMicroelectronics were tested in all the experiments. Tests with thermal and fast neutrons (up to about 10 MeV) at the TRIGA Mark II reactor showed that single-event burnout (SEB) failures only occurred at voltages close to the rated drain-source voltage. Thermal neutrons did not induce SEB, nor degradation in the electrical parameters of the devices. SEB failures during testing at ChipIr …

A Compact Solid State Detector for Small Angle Particle Tracking

MIDAS (MIcrostrip Detector Array System) is a compact silicon tracking telescope for charged particles emitted at small angles in intermediate energy photonuclear reactions. It was realized to increase the angular acceptance of the DAPHNE detector and used in an experimental program to check the Gerasimov-Drell-Hearn sum rule at the Mainz electron microtron, MAMI. MIDAS provides a trigger for charged hadrons, p/pi identification and particle tracking in the region 7 deg < theta < 16 deg. In this paper we present the main characteristics of MIDAS and its measured performances.

Boron determination in liver tissue by combining quantitative neutron capture radiography (QNCR) and histological analysis for BNCT treatment planning at the TRIGA Mainz.

The typical primary malignancies of the liver are hepatocellular carcinoma and cholangiocarcinoma, whereas colorectal liver metastases are the most frequently occurring secondary tumors. In many cases, only palliative treatment is possible. Boron neutron capture therapy (BNCT) represents a technique that potentially destroys tumor tissue selectively by use of externally induced, locally confined secondary particle irradiation. In 2001 and 2003, BNCT was applied to two patients with colorectal liver metastases in Pavia, Italy. To scrutinize the rationale of BNCT, a clinical pilot study on patients with colorectal liver metastases was carried out at the University of Mainz. The distribution o…

Total photoabsorption cross sections forH1,H2, andHe3from 200 to 800 MeV

The total photoabsorption cross sections for $^{1}\mathrm{H}$, $^{2}\mathrm{H}$, and $^{3}\mathrm{He}$ have been measured for incident photon energies ranging from 200 to 800 MeV. The $^{3}\mathrm{He}$ data are the first for this nucleus. By using the large acceptance detector DAPHNE in conjunction with the tagged photon beam facility of the MAMI accelerator in Mainz, cross sections of high precision have been obtained. The results show clearly the changes in the nucleon resonances in going from $^{1}\mathrm{H}$ to $^{3}\mathrm{He}$. In particular, for the ${\mathit{D}}_{13}$ region the behavior for $^{3}\mathrm{He}$ is intermediate between that for $^{1}\mathrm{H}$, $^{2}\mathrm{H}$, and h…

First Measurement of the Gerasimov-Drell-Hearn Sum Rule forH1from 0.7 to 1.8 GeV at ELSA

To verify the fundamental Gerasimov-Drell-Hearn (GDH) sum rule for the first time experimentally, we measured the helicity dependent total photoabsorption cross section with circularly polarized real photons and longitudinally polarized nucleons in the photon energy range 0.68-1.82 GeV with the tagged photon facility at ELSA. The experiment was carried out with a 4pi detection system, a circularly polarized tagged photon beam, and a frozen spin polarized proton target. The contribution to the GDH sum rule in this photon energy range is [49.9+/-2.4(stat)+/-2.2(syst)] mub.

A polarized 3He target for the photon beam at MAMI

Abstract A polarized 3 He target has been installed for the first time inside the 4 π Crystal Ball detector at the tagged photon beam of the MAinz MIcrotron (MAMI). It has been demonstrated that the system works reliably and that the polarization losses during handling of the polarized gas are under control. Initial polarization values up to 70% and total relaxation times up to 20 h could be obtained during a first test beam time devoted to the measurement of the double polarized photoabsorption cross-section in the Δ ( 1232 ) baryon resonance region.

Measurement of Helicity-Dependent Photoabsorption Cross Sections on the Neutron from 815 to 1825 MeV

Helicity-dependent total photoabsorption cross sections on the deuteron have been measured for the first time at ELSA (Bonn) in the photon energy range from 815 to 1825 MeV. Circularly polarized tagged photons impinging on a longitudinally polarized LiD target have been used together with a highly efficient 4pi detector system. The data around 1 GeV are not compatible with predictions from existing multipole analyses. From the measured energy range an experimental contribution to the GDH integral on the neutron of [33.9 +/- 5.5(stat) +/- 4.5(syst)] microb is extracted.

Two-body photodisintegration of the deuteron from 100 to 800 MeV

Abstract The total and the differential cross sections for the D(γ,p)n reaction have been measured over the photon energy range 100-800 MeV at the 855 MeV MAMI Microtron in Mainz. Using the large acceptance detector DAPHNE in conjunction with the Glasgow tagging spectrometer, high precision results with small systematic errors were obtained. The data are presented in the form of thirty-five angular distributions at c.m. proton angles between 30°–160° in 10° intervals and at photon energies in steps of 20 MeV. Previous experimental work is reassessed in the light of the present results and comparison with some recent theoretical calculations.

Potentialities of High-Resolution 3-D CZT Drift Strip Detectors for Prompt Gamma-Ray Measurements in BNCT

Recently, new high-resolution cadmium–zinc–telluride (CZT) drift strip detectors for room temperature gamma-ray spectroscopic imaging were developed by our group. The CZT detectors equipped with orthogonal anode/cathode collecting strips, drift strips and dedicated pulse processing allow a detection area of 6 × 20 mm2 and excellent room temperature spectroscopic performance (0.82% FWHM at 661.7 keV). In this work, we investigated the potentialities of these detectors for prompt gamma-ray spectroscopy (PGS) in boron neutron capture therapy (BNCT). The detectors, exploiting the measurement of the 478 keV prompt gamma rays emitted by 94% 7Li nuclides from the 10B(n, α)7…

High performance 3D CZT spectro-imager for BNCT-SPECT: preliminary characterization

The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10 B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10 B(n,α) 7 Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10 B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell…

Measurement of the Gerasimov-Drell-Hearn Integrand forH2from 200 to 800 MeV

A measurement of the helicity dependence of the total inclusive photoabsorption cross section on the deuteron was carried out at MAMI (Mainz) in the energy range $200l{E}_{\ensuremath{\gamma}}l800\text{ }\text{ }\mathrm{MeV}$. The experiment used a $4\ensuremath{\pi}$ detection system, a circularly polarized tagged photon beam and a frozen-spin target which provided longitudinally polarized deuterons. The contribution to the Gerasimov-Drell-Hearn sum rule for the deuteron determined from the data is $407\ifmmode\pm\else\textpm\fi{}20(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}24(\mathrm{syst})\text{ }\text{ }\ensuremath{\mu}\mathrm{b}$ for $200l{E}_{\ensuremath{\gamma}}l800\text{ }\text{ }\m…

Helicity dependence of the total inclusive cross section on the deuteron

Abstract A measurement of the helicity dependence of the total inclusive photoabsorption cross section on the deuteron was carried out at MAMI (Mainz) in the energy range 200 E γ 800 MeV . The experiment used a 4 π detection system, a circularly polarized tagged photon beam and a frozen spin target which provided longitudinally polarized deuterons. These new results are a significant improvement on the existing data and allow a detailed comparison with state-of-the-art calculations.

New Results on High-Resolution 3-D CZT Drift Strip Detectors

Intense research activities have been carry out in the development of room temperature gamma ray spectroscopic imagers, aiming to compete with the excellent energy resolution of high-purity germanium (HPGe) detectors (0.3 % FWHM at 662 keV) obtained after cryogenic cooling. Cadmium-zinc-telluride (CZT) detectors equipped with pixel, strip and virtual Frisch-grid electrode structures represented an appealing solution for room temperature measurements. In this work, we present the performance of new high-resolution CZT drift strip detectors (19.4 x 19.4 x 6 mm3), recently fabricated at IMEM-CNR of Parma (Italy) in collaboration with due2lab company (Reggio Emilia, Italy). The detectors, worki…

Helicity Dependence ofγp→Nπbelow 450 MeV and Contribution to the Gerasimov-Drell-Hearn Sum Rule

The helicity dependence of the single pion photoproduction on the proton has been measured in the energy range from 200 to 450 MeV for the first time. The experiment, performed at the Mainz microtron MAMI, used a 4pi-detector system, a circularly polarized, tagged photon beam, and a frozen-spin target. The data obtained provide new information for multipole analyses of pion photoproduction and determine the main contributions to the Gerasimov-Drell-Hearn sum rule and the forward spin polarizability gamma(0).

Recent advances in the development of high-resolution 3D cadmium-zinc-telluride drift strip detectors.

In the last two decades, great efforts have been made in the development of 3D cadmium–zinc–telluride (CZT) detectors operating at room temperature for gamma-ray spectroscopic imaging. This work presents the spectroscopic performance of new high-resolution CZT drift strip detectors, recently developed at IMEM-CNR of Parma (Italy) in collaboration with due2lab (Italy). The detectors (19.4 mm × 19.4 mm × 6 mm) are organized into collecting anode strips (pitch of 1.6 mm) and drift strips (pitch of 0.4 mm) which are negatively biased to optimize electron charge collection. The cathode is divided into strips orthogonal to the anode strips with a pitch of 2 mm. Dedicated pulse processing analysis…