0000000000061406
AUTHOR
Michael Leuck
ChemInform Abstract: Synthesis of Active Principles from the Leaves of Moringa oleifera Using S-Pent-4-enyl Thioglycosides.
Abstract α - l -Rhamnosides of 4-hydroxy-benzyl compounds with nitrile, carbamate, and thiocarbamate groups occurring in Moringa oleifera leaf extracts and the α - l -rhamnoside of anisaldehyde derivatives were synthesised. Electrophilic activation of S -pent-4-enyl thiorhamnosides was applied for the construction of glycosidic linkages.
Structure analysis of acetylated and non-acetylated O-linked MUC1-glycopeptides by post-source decay matrix-assisted laser desorption/ionization mass spectrometry.
We have investigated the potential of structural elucidation of O-linked glycopeptides by post-source decay matrix-assisted laser desorption ionization mass spectrometry (PSD-MALDI-MS). In order to establish detailed fragmentation patterns and to dissect fragment ions with and without carbohydrate content, the same O-linked MUC1-derived glycopeptides with acetylated and non-acetylated sugars were analysed and compared. Furthermore, we were interested to examine possible differences in the fragmentation between glycopeptides with acetylated and non-acetylated sugars. The obtained PSD-MALDI-MS spectra showed a rather complete set of fragmentation data which allows us to localize the glycan on…
ChemInform Abstract: Synthesis of TN and T Antigen Glycopeptide Sequences of Tumor- Associated MUC-1 Using S-Pent-4-enyl Thioglycosides.
The synthesis of glycopeptides 34 and 38 with tumor associated TN and T antigen structure containing a partial sequence of the tandem repeat unit of the polymorphic epithelial mucin MUC-1 were achieved via fragment condensations. Electrophilic activation of S-pent-4-enyl thioglycosides was appiled for the construction of O-glycosyl amino and saccharide building blocks.
Synthesis of active principles from the leaves of Moringa oleifera using S-pent-4-enyl thioglycosides
Abstract α - l -Rhamnosides of 4-hydroxy-benzyl compounds with nitrile, carbamate, and thiocarbamate groups occurring in Moringa oleifera leaf extracts and the α - l -rhamnoside of anisaldehyde derivatives were synthesised. Electrophilic activation of S -pent-4-enyl thiorhamnosides was applied for the construction of glycosidic linkages.