6533b852fe1ef96bd12ab61a
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of TN and T Antigen Glycopeptide Sequences of Tumor- Associated MUC-1 Using S-Pent-4-enyl Thioglycosides.
Horst KunzMichael Leucksubject
chemistry.chemical_classificationTandem repeatchemistryAntigenStereochemistryGeneral MedicineMuc1 MucinGlycopeptideAmino aciddescription
The synthesis of glycopeptides 34 and 38 with tumor associated TN and T antigen structure containing a partial sequence of the tandem repeat unit of the polymorphic epithelial mucin MUC-1 were achieved via fragment condensations. Electrophilic activation of S-pent-4-enyl thioglycosides was appiled for the construction of O-glycosyl amino and saccharide building blocks.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-03 | ChemInform |