0000000000064279

AUTHOR

Caterina Petrillo

showing 2 related works from this author

IRIDE: Interdisciplinary research infrastructure based on dual electron linacs and lasers

2014

This paper describes the scientific aims and potentials as well as the preliminary technical design of RUDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of sci…

Nuclear and High Energy PhysicsHigh energySC Linac;Neutron source;FEL;Compton source;Advanced accelerators concepts;Particle physicsSettore FIS/07 - FISICA APPLICATA (A BENI CULTURALI AMBIENTALI BIOLOGIA E MEDICINA)Advanced accelerators conceptTechnical designNOAdvanced accelerators conceptsParticle physicSC Linac; FEL; Particle physics; Neutron source; Compton source; Advanced accelerators conceptsInstrumentationFELPhysicsSC LinacSettore FIS/01 - Fisica SperimentaleAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linac; Instrumentation; Nuclear and High Energy PhysicsParticle physicsAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linac; Nuclear and High Energy Physics; InstrumentationCompton sourceNeutron sourceWide fieldSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Dual (category theory)Free Electron LaserAdvanced accelerators concepts Compton source FEL Neutron source Particle physics SC LinacAdvanced accelerators concepts; Compton source; FEL; Neutron source; Particle physics; SC Linacadvanced accelerators concepts; particle physics; sc linac; compton source; fel; neutron sourceneutron sourcefree electron lasersSystems engineeringFactory (object-oriented programming)Free electron laser
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The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

2021

AbstractThe maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease Mpro to cleave the virus-encoded polyproteins. Despite a wealth of experimental information already available, there is wide disagreement about the Mpro monomer-dimer equilibrium dissociation constant. Since the functional unit of Mpro is a homodimer, the detailed knowledge of the thermodynamics of this equilibrium is a key piece of information for possible therapeutic intervention, with small molecules interfering with dimerization being potential broad-spectrum antiviral drug leads. In the present study, we exploit Small Angle X-ray Scattering (…

0301 basic medicineMolecular biologyProtein ConformationSciencemedicine.medical_treatmentDimerBiophysicsPlasma protein binding010402 general chemistryAntiviral Agents01 natural sciencesArticleDissociation (chemistry)03 medical and health scienceschemistry.chemical_compoundProtein structureX-Ray DiffractionDrug DiscoverymedicineHumansProtease InhibitorsCoronavirus 3C ProteasesVirtual screeningMultidisciplinaryProteaseSARS-CoV-2ChemistryQSARS-CoV-2 main protease Mpro enzymatic activity inhibition Small Angle X-ray Scattering small inhibitors virtual screeningRCOVID-19Computational BiologySmall moleculeComputational biology and bioinformatics0104 chemical sciencesMolecular Docking SimulationDissociation constant030104 developmental biologyBiophysicsMedicineThermodynamicsDimerizationProtein Binding
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