0000000000066964

AUTHOR

M. Aurora Falcone

showing 2 related works from this author

Failure to find association between childhood abuse and cognition in first-episode psychosis patients

2012

AbstractThis study investigated the relationship between severe childhood abuse and cognitive functions in first-episode psychosis patients and geographically-matched controls. Reports of any abuse were associated with lower scores in the executive function domain in the control group. However, in contrast with our hypothesis, no relationships were found amongst cases.

AdultMaleChild abusemedicine.medical_specialtyPsychosisAdolescentExecutive FunctionYoung Adult03 medical and health sciences0302 clinical medicineSettore M-PSI/08 - Psicologia ClinicaFirst episode psychosismedicineHumansChild AbuseYoung adultChildPsychiatryAssociation (psychology)Settore MED/25 - PsichiatriaChildhood abuseAgedSchizophrenia and psychosiCase-control studyCognitionMiddle Agedmedicine.disease030227 psychiatryPsychiatry and Mental healthPsychotic DisordersSocial and cross-cultural psychiatryCase-Control StudiesFemaleCognition DisordersPsychology030217 neurology & neurosurgeryClinical psychologyEuropean Psychiatry
researchProduct

Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

2012

Background Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. Methods In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of psychosis. Results The rs2494732 locus was not associated with an increased risk of a psychotic disorder, with lifetime cannabis use, or with frequency of use. We did, however, find that the effect of lifetime cannabis use on risk of psychosis was significantly influenced by the rs24947…

AdultMalemedicine.medical_specialtyPsychosisMarijuana AbuseEpisode of CarePolymorphism Single NucleotideRisk AssessmentOddsInternational Classification of DiseasesRisk FactorsLondonSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.medicineConfidence IntervalsOdds RatioHumansGenetic Predisposition to DiseaseGenetic TestingGene–environment interactionPsychiatrySettore MED/25 - PsichiatriaBiological PsychiatryDemographybiologyCase-control studyOdds ratiomedicine.diseasebiology.organism_classificationConfidence intervalPsychotic DisordersSocioeconomic FactorsCase-Control StudiesFemaleGene-Environment InteractionAKT1 gene cannabis use gene environment interaction psychosis schizophrenia signaling pathwaysCannabisRisk assessmentPsychologyProto-Oncogene Proteins c-aktDemographyBiological psychiatry
researchProduct