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Relation of childhood brain tumors to exposure of parents and children to tobacco smoke: The Search international case-control study

The etiology of childhood brain tumors (CBTs) remains unknown. Tobacco smoke contains several known carcinogens and can induce DNA adducts in human placenta and hemoglobin adducts in fetuses. We present the results of an international case-control study to evaluate the association between CBTs and exposure of parents and children to cigarette smoke. The study was undertaken as part of the SEARCH program of the IARC. Nine centers in 7 countries were involved. The studies mainly covered the 1980s and early 1990s. Cases (1,218, ages 0-19 years) were children newly diagnosed with a primary brain tumor; there were 2,223 population-based controls. Most mothers who agreed to participate were inter…

Need for global action for cancer control.

Kl3Semileptonic Form Factor from (2+1)-Flavor Lattice QCD

We present the first results for the ${K}_{l3}$ form factor from simulations with $2+1$ flavors of dynamical domain wall quarks. Combining our result, namely, ${f}_{+}(0)=0.964(5)$ with the latest experimental results for ${K}_{l3}$ decays leads to $|{V}_{us}|=0.2249(14)$, reducing the uncertaintity in this important parameter. For the $O({p}^{6})$ term in the chiral expansion we obtain $\ensuremath{\Delta}f=\ensuremath{-}0.013(5)$.

Kl3form factor withNf= 2 +1 dynamical domain wall fermions

We present the latest results from the UKQCD/RBC collaborations for the Kl3 form factor from simulations with 2 + 1 flavours of dynamical domain wall quarks. Simulations are performed on lattices with two different volumes and four values of the light quark mass, allowing for an extrapolation to the chiral limit. The analysis includes a thorough investigation into the sources of systematic error in our fits. After interpolating to zero momentum transfer, we obtain f+(0) = 0.964(5) (or ?f = -0.013(5)) which, when combined with the latest experimental results for Kl3 decays, leads to |Vus| = 0.2249(14).

Tobacco: deadly in any form or disguise

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9). © 2010 Nature America, Inc. All rights reserved.