6533b86efe1ef96bd12ccb42

RESEARCH PRODUCT

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Neil E. KayJacques RibyBengt GlimeliusScott DavisSusan L. SlagerMaryjean SchenkHui Qi LowNathaniel RothmanYolanda BenaventeNicola J. CampLogan G. SpectorJianjun LiuLaura Z. RassentiSara S. StromMark P. PurdueKarin E. SmedbyPaul BrennanSilvia De SanjoséTongzhang ZhengQing LanWendy CozenJulie M. CunninghamMartha GlennHenrik HjalgrimChristine F. SkibolaBruce K. ArmstrongCeline M. VachonLenka ForetovaSara J. AchenbachAlexandra NietersPaolo BoffettaMarc MaynadiéLynn R. GoldinPeter BoyleSophia S. WangEran HalperinStephen J. ChanockPatricia HartgeHans-olov AdamiKari G. RabeSam MillikenKatja ButterbachKevin M. BrownNikolaus BeckerLindsay M. MortonPierluigi CoccoKeith HumphreysYawei ZhangNeil E. CaporasoClaire M. VajdicMark C. LanasaAnne KrickerJohn J. SpinelliEllen T. ChangGerald E. MartiMads MelbyeHatef DarabiAnthony StainesLucia CondeJose F. LeisTimothy G. CallMartyn T. SmithCurtis A. HansonNicholas K. AkersElizabeth A. HollyLuz AganaJ. Brice WeinbergShelia Hoar ZahmPaige M. BracciJames R. CerhanAngela Brooks-wilson

subject

Chronic lymphocytic leukemiaFollicular lymphomaLocus (genetics)Genome-wide association studyHuman leukocyte antigenBiologyArticleMajor Histocompatibility Complex03 medical and health sciences0302 clinical medicinefollicular lymphomaRisk Factorshemic and lymphatic diseasesGeneticsmedicineHumansLymphoma Follicular030304 developmental biology0303 health sciencesLymphoma Non-HodgkinGenetic Variation16. Peace & justicemedicine.diseaseLeukemia Lymphocytic Chronic B-Cell3. Good healthLymphomaNon-Hodgkin's lymphomaLeukemia030220 oncology & carcinogenesisImmunologyDisease SusceptibilityGenome-Wide Association Study

description

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9). © 2010 Nature America, Inc. All rights reserved.

yearjournalcountryeditionlanguage
2010-04-02
10.1038/ng.626http://hdl.handle.net/11585/682136