0000000000006009
AUTHOR
Scott Davis
showing 23 related works from this author
Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
2014
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the fifth most common type of cancer in more developed regions of the world (1). Numerous NHL subtypes with distinct combinations of morphologic, immunophenotypic, genetic, and clinical features are currently recognized (2,3). The incidence of NHL subtypes varies substantially by age, sex, and race/ethnicity (4–7). However, the etiological implications of this biological, clinical, and epidemiological diversity are incompletely understood. The importance of investigating etiology by NHL subtype is clearly supported by research on immunosuppression, infections, and autoimmune diseases, which are the strongest and most e…
Search for short baseline nu(e) disappearance with the T2K near detector
2015
8 pages.- 6 figures
T2K neutrino flux prediction
2013
The Tokai-to-Kamioka (T2K) experiment studies neutrino oscillations using an off-axismuon neutrino beam with a peak energy of about 0.6 GeV that originates at the Japan Proton Accelerator Research Complex accelerator facility. Interactions of the neutrinos are observed at near detectors placed at 280 m from the production target and at the far detector-Super-Kamiokande-located 295 km away. The flux prediction is an essential part of the successful prediction of neutrino interaction rates at the T2K detectors and is an important input to T2K neutrino oscillation and cross section measurements. A FLUKA and GEANT3-based simulation models the physical processes involved in the neutrino producti…
Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector
2012
Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The …
Effects of Ultraviolet Photoactivation on Osseointegration of Commercial Pure Titanium Dental Implant After 8 Weeks in a Rabbit Model
2020
This study investigated whether a 6-Watt ultraviolet C-lamp was capable of producing photofunctionalization on commercial implants during a medium observation term of 8 weeks. A total of 20 implants were inserted in 5 New Zealand rabbits, with each animal receiving 2 implants per tibia (one photofunctionalized and one untreated), according to a previously established randomization sequence. All implants were inserted by a single surgeon following the manufacturer's instructions. Histological analysis was performed by an evaluator who was blinded to the treatment condition. After 8 weeks of healing, the 2 groups showed no statistically significant differences in terms of bone-to-implant cont…
Measurement of the $\nu_{\mu}$ charged current quasi-elastic cross-section on carbon with the T2K on-axis neutrino beam
2015
17 pages.- 21 figures
HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes
2018
Abstract A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of “heterozygote advantage” regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL…
Measurement of the inclusive $\nu_{\mu}$ charged current cross section on iron and hydrocarbon in the T2K on-axis neutrino beam
2014
We report a measurement of the $\nu_\mu$ inclusive charged current cross sections on iron and hydrocarbon in the T2K on-axis neutrino beam. The measured inclusive charged current cross sections on iron and hydrocarbon averaged over the T2K on-axis flux with a mean neutrino energy of 1.51 GeV are $(1.444\pm0.002(stat.)_{-0.157}^{+0.189}(syst.))\times 10^{-38}\mathrm{cm}^2/\mathrm{nucleon}$, and $(1.379\pm0.009(stat.)_{-0.147}^{+0.178}(syst.))\times 10^{-38}\mathrm{cm}^2/\mathrm{nucleon}$, respectively, and their cross section ratio is $1.047\pm0.007(stat.)\pm0.035(syst.)$. These results agree well with the predictions of the neutrino interaction model, and thus we checked the correct treatme…
Observation of Electron Neutrino Appearance in a Muon Neutrino Beam
2014
The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3$\sigma$ when compared to 4.92 $\pm$ 0.55 expected background events. In the PMNS mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles $\theta_{12}$, $\theta_{23}$, $\theta_{13}$, a mass difference $\Delta m^2_{32}$ and a CP violating phase $\delta_{\mathrm{CP}}$. In this neutrino oscillation scenario, assuming $…
Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.
2015
Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as prim…
Non-Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph consortium
2008
Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m-2 or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL …
Indication of electron neutrino appearance from an accelerator-produced off-axis muon neutrino beam
2011
The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumulated with $1.43\times10^{20}$ protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with $|\Delta m_{23}^2|=2.4\times10^{-3}$ eV$^2$, $\sin^2 2\theta_{23}=1$ and $\sin^2 2\theta_{13}=0$, the expected number of such events is 1.5$\pm$0.3(syst.). Under this hypothesis, the probability to observe six or more candidate events is 7$\times10^{-3}$, equivalent to 2.5$\sigma$ significance. At 90% C.L., the data are consistent with 0.03(0.04)$<\sin^2 2\theta_{13}<$ 0.28(0.34) for $\delta_{\rm CP}=0$ and a normal (inverted) hierarchy.
Measurement of theνμcharged-current quasielastic cross section on carbon with the ND280 detector at T2K
2015
We thank the J-PARC staff for superb accelerator performance and the CERN NA61 Collaboration for providing valuable particle production data. We acknowledge the support of MEXT, Japan; NSERC, NRC, and CFI, Canada; CEA and CNRS/IN2P3, France; DFG, Germany; INFN, Italy; National Science Centre (NCN), Poland; RSF, RFBR, and MES, Russia; MINECO and ERDF funds, Spain; SNSF and SER, Switzerland; STFC, UK; and DOE, USA. We also thank CERN for the UA1/NOMAD magnet, DESY for the HERA-B magnet mover system, NII for SINET4, the WestGrid and SciNet consortia in Compute Canada, GridPP, UK. In addition participation of individual researchers and institutions has been further supported by funds from ERC (…
First Muon-Neutrino Disappearance Study with an Off-Axis Beam
2012
We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment. With data corresponding to 1.43 × 10(20) protons on target, we observe 31 fully-contained single μ-like ring events in Super-Kamiokande, compared with an expectation of 104 ± 14(syst) events without neutrino oscillations. The best-fit point for two-flavor νμ → ντ oscillations is sin 2(2θ(23)) = 0.98 and |Δm(2)(32)| = 2.65 × 10(−3) eV2. The boundary of the 90% confidence region includes the points (sin2 (2θ(23)), |Δm(2)(32)|) = (1.0, 3.1 × 10(−3) eV2), (0.84, …
Precise measurement of the neutrino mixing parameter θ23 from muon neutrino disappearance in an off-axis beam
2014
New data from the T2K neutrino oscillation experiment produce the most precise measurement of the neutrino mixing parameter theta_{23}. Using an off-axis neutrino beam with a peak energy of 0.6 GeV and a data set corresponding to 6.57 x 10^{20} protons on target, T2K has fit the energy-dependent nu_mu oscillation probability to determine oscillation parameters. Marginalizing over the values of other oscillation parameters yields sin^2 (theta_{23}) = 0.514 +0.055/-0.056 (0.511 +- 0.055), assuming normal (inverted) mass hierarchy. The best-fit mass-squared splitting for normal hierarchy is Delta m^2_{32} = (2.51 +- 0.10) x 10^{-3} eV^2/c^4 (inverted hierarchy: Delta m^2_{13} = (2.48 +- 0.10) …
Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear deexcitation gamma rays
2014
We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation $\gamma$-rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to $3.01 \times 10^{20}$ protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the $4-30$ MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background …
Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis
2009
AbstractWe performed a pooled analysis of data on atopic disease and risk of non–Hodgkin lymphoma (NHL) from 13 case-control studies, including 13,535 NHL cases and 16,388 controls. Self-reported atopic diseases diagnosed 2 years or more before NHL diagnosis (cases) or interview (controls) were analyzed. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were computed in two-stage random-effects or joint fixed-effects models, and adjusted for age, sex, and study center. When modeled individually, lifetime history of asthma, hay fever, specific allergy (excluding hay fever, asthma, and eczema), and food allergy were associated with a significant reduction in NHL risk, and there wa…
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
2010
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9). © 2010 Nature America, Inc. All rights reserved.
Measurement of the Inclusive NuMu Charged Current Cross Section on Carbon in the Near Detector of the T2K Experiment
2013
T2K has performed the first measurement of nu(mu) inclusive charged current interactions on carbon at neutrino energies of similar to 1 GeV where the measurement is reported as a flux-averaged double differential cross section in muon momentum and angle. The flux is predicted by the beam Monte Carlo and external data, including the results from the NA61/SHINE experiment. The data used for this measurement were taken in 2010 and 2011, with a total of 10.8 x 10(19) protons-on-target. The analysis is performed on 4485 inclusive charged current interaction candidates selected in the most upstream fine-grained scintillator detector of the near detector. The flux-averaged total cross section is (…
Measurement of the Inclusive Electron Neutrino Charged Current Cross Section on Carbon with the T2K Near Detector
2014
The T2K off-axis near detector, ND280, is used to make the first differential cross-section measurements of electron neutrino charged current interactions at energies ~1 GeV as a function of electron momentum, electron scattering angle and four-momentum transfer of the interaction. The total flux-averaged $\nu_e$ charged current cross-section on carbon is measured to be $1.11\pm0.09~(stat)\pm0.18~(syst)\times10^{-38} cm^2/nucleon$. The differential and total cross-section measurements agree with the predictions of two leading neutrino interaction generators, NEUT and GENIE. The NEUT prediction is $1.23\times10^{-38} cm^2/nucleon$ and the GENIE prediction is $1.08\times10^{-38} cm^2/nucleon$…
The T2K Experiment
2011
The T2K experiment is a long-baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle {\theta}_{13} by observing {\nu}_e appearance in a {\nu}_{\mu} beam. It also aims to make a precision measurement of the known oscillation parameters, {\Delta}m^{2}_{23} and sin^{2} 2{\theta}_{23}, via {\nu}_{\mu} disappearance studies. Other goals of the experiment include various neutrino cross section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande)…
Evidence of Electron Neutrino Appearance in a Muon Neutrino Beam
2013
The T2K Collaboration reports evidence for electron neutrino appearance at the atmospheric mass splitting, vertical bar Delta m(32)(2)vertical bar approximate to 2.4 X 10(-3) eV(2). An excess of electron neutrino interactions over background is observed from a muon neutrino beam with a peak energy of 0.6 GeV at the Super-Kamiokande (SK) detector 295 km from the beam's origin. Signal and background predictions are constrained by data from near detectors located 280 m from the neutrino production target. We observe 11 electron neutrino candidate events at the SK detector when a background of 3.3 +/- 0.4(syst) events is expected. The background-only hypothesis is rejected with a p value of 0.0…
Effect of Rotary Instrument Mineral Oil Lubricant on Osseointegration: A Randomized, Blinded Study in Rabbits
2019
The mechanisms of early failures in dental implant osseointegration are unclear. A possible cause of low levels of bone formation is lubricant contamination on implants during insertion. To explore the impact of lubricant contamination on dental implants, we used 5 New Zealand rabbits and inserted 2 implants per tibia in each animal for a total of 4 implants per animal (20 implants in total). In general, bicorticalization was achieved. The first implant was placed as suggested by the manufacturer with no lubricant used (control). The second implant was placed using a freshly lubricated contra-angle handpiece, which was used only for the test implants. Implant allocation was randomized, and …