Frailty and leucocyte count are predictors of all-cause mortality and hospitalization length in non-demented institutionalized older women.

Alteration in the immune system such as the number of white blood cells count (WBC) has been associated with frailty syndrome but their role in institutionalized older individuals have been rarely investigated. We evaluated the relationships between white blood cell subtypes, geriatric assessment, depression and frailty syndrome based on the criteria of physical phenotype. In particular, we aimed to analyze by a two-year follow-up and prospective study the predictive value of alterations in WBC, frailty and functional impairment in terms of hospitalizations and all-cause mortality in institutionalized older women. There was a significant and inverse correlation between the frailty score and…

The value of neutrophil and lymphocyte count in frail older women.

Increasing evidence suggests that systemic inflammation is associated with many pathophysiological processes including frailty in older adults. We evaluated the relationships between white blood cell subtypes, geriatric assessment, and frailty syndrome and in particular, how they correlate with individual frailty criteria (involuntary loss of weight, low energy or exhaustion, slow mobility, muscle weakness, and low physical activity) in frail older women. There was a significant and positive correlation between the frailty score and neutrophil count, but a significantly negative correlation was found when this score was compared to the lymphocyte count. These associations were significant o…

Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review

Frailty is a geriatric syndrome characterized by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Individuals with one or two of these alterations are defined as prefrail. The clinical features of prefrail older individuals have been investigated to a lesser extent compared to the frail population, even though this intermediate stage may provide insights into the mechanisms involved in the physical decline associated with aging and it is considered to be potentially reversible. We performed searches in the Medline, Embase, Scopus, Cinahl, and Cochrane databases from Ja…

The relationship between depression and frailty syndrome: a systematic review

Frailty is a geriatric syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of frailty syndrome or vice versa or these two coexist independently in the same individuals.We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about frailty syndrome and depression in people aged 65 and older published and the …

Valor predictivo de la presentación clínica del dolor torácico en el diagnóstico de los síndromes coronarios agudos

Fundamento y objetivo Presentamos la utilidad diagnostica de la cuantificacion del dolor toracico en pacientes con dolor toracico de posible origen coronario. Pacientes y metodo Se estudio a 1.068 pacientes consecutivos que acudieron a un servicio de urgencias por dolor toracico de posible origen coronario sin elevacion del segmento ST, siguiendo un protocolo de unidad de dolor toracico. El dolor toracico se cuantifico mediante un sistema de puntuacion (0 a 20 puntos). Se determino el valor diagnostico de la puntuacion de dolor toracico para predecir el diagnostico final de infarto agudo de miocardio (IAM), angina inestable (AI) y sindrome coronario agudo (SCA; IAM o AI). Resultados Se diag…

P120: The value of neutrophil and lymphocyte count in frail older women