0000000000069035

AUTHOR

Giacoma Di Vieste

showing 3 related works from this author

Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

2013

Context: This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with metabolic syndrome (MetS). Objective: Our objective was to assess the effects of genistein on surrogate endpoints associated with diabetes and cardiovascular disease. Design and Setting: This was a randomized, double-blind, placebo-controlled trial at 3 university medical centers in Italy. Patients: Patients included 120 postmenopausal women with MetS according to modified Third Report of the National Cholesterol Education Program (NCEP), Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Tre…

medicine.medical_specialtyCardiovascular Risk Factorsgenistein aglycone; metabolic syndrome; Cardiovascular Risk FactorsEndocrinology Diabetes and MetabolismClinical BiochemistryContext (language use)PlaceboBiochemistrylaw.inventionEndocrinologyInsulin resistanceDouble-Blind MethodRandomized controlled triallawDiabetes mellitusInternal medicinemedicineHumansgenistein aglyconeNational Cholesterol Education ProgramAgedMetabolic SyndromeSurrogate endpointbusiness.industryMetabolic Syndrome XCholesterol HDLBiochemistry (medical)Cholesterol LDLMiddle Agedmedicine.diseaseGenisteinEndocrinologyFemaleInsulin ResistanceMetabolic syndromebusinessHumanThe Journal of Clinical Endocrinology & Metabolism
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Genistein and endothelial function in postmenopausal women with metabolic syndrome

2013

BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brach…

medicine.medical_specialtyHomocysteineClinical BiochemistryGenisteinmenopausePhytoestrogensPilot ProjectsVasodilationPlaceboBiochemistrymetabolic syndromeClinical studygenisteinchemistry.chemical_compoundendothelial functionmedicine.arteryInternal medicinemedicineHumansAnkle Brachial IndexBrachial arteryAdiponectinbusiness.industryClinical study; Endothelial function; Genistein; Menopause; Metabolic syndromeGeneral MedicineMiddle Agedmedicine.diseasePostmenopauseVasodilationMenopauseTreatment OutcomeEndocrinologychemistryFemaleEndothelium VascularMetabolic syndromebusiness
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Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study

2017

Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurement…

Cardiac function curvemedicine.medical_specialtycardiac function; echocardiography; genistein; menopause; metabolic syndromegenistein; metabolic syndrome; menopause; cardiac function; echocardiographyGenisteinlcsh:TX341-641030204 cardiovascular system & hematologyPlaceboArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDouble-Blind MethodInterquartile rangeInternal medicinemedicineHumans030212 general & internal medicineEnd-systolic volumeBody surface areaNutrition and DieteticsEjection fractionbusiness.industryCardiac functionHeartMiddle Agedmedicine.diseaseGenisteinMetabolic syndromePostmenopauseEndocrinologychemistryEchocardiographyDietary SupplementsCardiologyCardiac function; Echocardiography; Genistein; Menopause; Metabolic syndrome; Food ScienceFemaleMetabolic syndromeMenopausebusinesslcsh:Nutrition. Foods and food supplyFood Science
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