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RESEARCH PRODUCT

Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study

Vincenzo ArcoraciGiuseppe LicataMarco AtteritanoCesare De GregorioRoberta GraneseCorrao SalvatoreElena Bianca AdamoAlessandra BittoHerbert MariniDomenica AltavillaAntonino Di BenedettoGiacoma Di ViesteFrancesco SquadritoConcetta IraceDiego PancaldoAngela Alibrandi

subject

Cardiac function curvemedicine.medical_specialtycardiac function; echocardiography; genistein; menopause; metabolic syndromegenistein; metabolic syndrome; menopause; cardiac function; echocardiographyGenisteinlcsh:TX341-641030204 cardiovascular system & hematologyPlaceboArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDouble-Blind MethodInterquartile rangeInternal medicinemedicineHumans030212 general & internal medicineEnd-systolic volumeBody surface areaNutrition and DieteticsEjection fractionbusiness.industryCardiac functionHeartMiddle Agedmedicine.diseaseGenisteinMetabolic syndromePostmenopauseEndocrinologychemistryEchocardiographyDietary SupplementsCardiologyCardiac function; Echocardiography; Genistein; Menopause; Metabolic syndrome; Food ScienceFemaleMetabolic syndromeMenopausebusinesslcsh:Nutrition. Foods and food supplyFood Science

description

Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. −1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.

yearjournalcountryeditionlanguage
2017-06-07
10.3390/nu9060584http://hdl.handle.net/10447/245102