A Novel HPLC-MS Method for Analysis of Plasma Sterols

AN HPLC/APCI METHOD, USING PARTLY MISCIBLE SOLVENTS, FOR A SIMPLE SEPARATION AND DETERMINATION OF STEROLS IN BLOOD

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular deat…

A Novel Liquid Chromatography/Mass Spectrometry Method for Analysis of Plasma Sterol Concentrations

A simple High Performance Liquid Chromatography-Mass spectrometry approach combined with Linear Discriminant Analysis for the characterization of top quality olive oils