Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

6533b7d6fe1ef96bd1265b02

RESEARCH PRODUCT

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

Green Jb Bethel Ma Armstrong Pw Buse Jb Engel Ss Garg J Josse R Kaufman Kd Koglin J Korn S Lachin Jm Mcguire Dk Pencina Mj Standl E Stein Pp Suryawanshi S Van De Werf F Peterson Ed Holman Rr Holman Rr Peterson Ed Holman Rr Peterson Ed Armstrong Pw Buse Jb Josse Rg Kaufman Kd Koglin J Korn S Lachin Jm Mcguire Dk Standl E Stein Pp Suryawanshi S Van De Werf F Engel Ss Califf Rm Goldstein Bj Shapiro Dr Silverman R Bethel A Green J Hayden S Hannan K Quintero K Rorick T Berdan L Leloudis D Califf S Wilson M Mcfarron D Trollinger K Pesarchick J Eskenazi L Campbell C Townes O Tolsma D Keenan J Milton J Athwal R Darbyshire J Doran Z Kennedy I Gregory V Garg J Lokhnygina Y Prather K Wolfley A Usman M Tajjar A Gray R Pfeffer Ma Gerstein Hc Groop L Mcmurray Jj Pocock Sj Clayton T Sinay I Brieger D Stranks S Scheen A Lopes R Tankova T Hramiak I Grado Cr Wenying Y Ge J Aschner P Skrha J Ambos A Strandberg T Travert F Hanefeld M Riefflin A Chan Jc Ofner P Reddy Nk Christopher J Mathur A Arambam P 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Ulla Mr Vico Ml Waitman Jn Binnekamp M Carroll P Cheung W Colman P Davis T De Looze F Demden M Fulcher G Gerstman M Hamilton A Lehman S Moses R Proietto J Roberts A Shaw J Simpson R Sinha A Stranks S Tan Y Topliss D Vora P Waites J Crenier L Descamps O Keymeulen B Mathieu C Nobels F Scheen A Van Den Bruel A Van Gaal L Borges Jl Costa E Forti A Eliaschewitz Fg Felício Js Griz Lh Hissa Mn Leite S Panarotto D Pimentel Filho P Rassi N Saraiva Jk Sgarbi Ja Silva Rp Tambascia M Weber Silva Dm Bobeva R Bostandzhieva R Cinlikov I Georgieva M Iliev D Ilieva E Kovacheva S Liubenova L Nikitov Z Sheinikova G Slavcheva A Spasova V Tankova T Temelkova-kurktschiev T Velichka D Yakov A Carpentier A Chiasson Jl Constance C Dumas R Filteau P Garceau C Hramiak I Huynh T Kaiser S Kornder J Leiter L Mereu L Miller D Pandey S Punthakee Z Rabasa-lhoret R Robitaille Y Saunders K Sigal R Sigalas J Vizel S Weisnagel S Woo V Yale Jf Yared K Zinman B Bunster Balocchi Lb Escobar Cerda Ee Garces Flores Ee Lanas Zanetti Ft Larrazabal Miranda Adel P Morales Alvarado Jm Olivares Cañon Cm Potthoff Cárdenas Sh Raffo Grado Ca Rodriguez Venegas Me Saavedra Gajardo Va Westerberg Maldonado Bh Chen Ll Dong J Guo X Li Qm Shi B Tang Xl Yang T Yang Wy Zheng Sx Aschner Montoya P Botero Lopez R Coronel Arroyo Ja Cure Ca Gómez Medina Am Molina Di Perez Amador Ga Reyes Rincon A Urina Triana Ma Valenzuela Rincon A Vélez Pelaez S Yupanqui Lozno H Brabec T Brychta T Hasalova Zapletalova J Havelkova J Hejnicova K Hola O Hornackova M Hrdina T Kafkova D Kellnerova I Krystl T Kutejova V Mikulkova I Nevrla J Pantlikova C Petr M Racicka E Sarbochova R Skrha J Smolenakova K Turcinek R Urbancova K Vejvodova J Vondrakova M Zachoval R Alt I Ambos A Kaasik Ü Kiiroja K Lanno R Märtsin K Past M Vides H Viitas L Kantola I Nieminen S Perhonen M Strand J Strandberg T Valle T Clergeot A Couffinhal T Courreges Jp Gouet D Moulin P Travert F Ziegler O Badenhoop K Behnke T Bender G Braun M Dshabrailov J Hamann A Hanefeld M Himpel-boenninghoff A Kamke W Kasperk C Luedemann J Mayr P Merkel M Oerter Em Ohlow Ma Ott P Overhoff U Paschen B Remppis R Riefflin A Rose L Schumm-draeger Pm Segiet T Strotmann Hj Stuchlik G Stürmer W Thinesse-mallwitz M Tytko A Wendisch U Wurziger J Ho Ay Kam G Kong Ap Lam Yy Lau Ey Lee S Siu Sc Tomlinson B Tsang Cc Yeung Vt Dezső E Dudás M Földesi I Fülöp T Késmárki N Koranyi L Nagy K Ofner P Oroszlán T Pécsvárady Z Ples Z Taller A Agarwal P Ambulkar S Aravind S Balaji V Christopher J Kalra S Kesavadev J Kudalkar H Kumar A Misra A Mithal A Mohan V Pitale S Ramu M Reddy N Shah S Shamanna P Sharda A Sharma A Shunmugavelu M Srikanta S Suryaprakash G Abramov G Adawi F Bashkin A Darawsha M Fuchs S Harman-boehm I Hayek T Jaffe A Knobler H Minuchin O Mosseri M Shechter M Shimon I Stern N Tsur A Vishlitzky V Wainstein J Alfonsi F Cavalot F Del Vecchio L Frisinghelli A Gambardella S Lauro D Lembo G Leotta S Mondillo S Novo S Pedrinelli R Piatti P Salvioni A Tritto I Zavaroni Dz Ahn Kj Choi Km Chung C Han Sj Kim Dm Kim Ij Kim Mh Lee Ik Nam M Park Ieb Park Ks Park Ts Park Y Rhee Ej Yoo Sj Andersone I Balode A Eglite R Gersamija A Kakurina N Jegere B Leitane I Pastare S Pirags V Stalte V Teterovska D Baltramonaitiene K Barsiene L Ceponis J Jakuboniene N Lasiene J Levinger A Sirutaviciene A Sulskiene M Urbanaviciene L Valius L Varanauskiene E Velickiene D Mahendran Ka Abu Hassan Mr Aziz Na Hussein Z Ismail Is Kamaruddin Na Mohamed M Nordin Z Nayar Sk Ramanathan Gr Sothiratnam R Beijerbacht H Breedveld R Cornel Jh Den Hartog F Hermans W Kietselaer B Kooy A Lenderink T Nierop P Remmen J Rojas Lingan G Ronner E Van Der Heijden R Van Hessen M Van Kempen W Voors-pette C Westendorp I Baker J Benatar J Cutfield R Krebs J Leikis R Lunt H Manning P Scott R Williams M Birkeland K Claudi T Halvorsen S Istad H Karlsson T Ossum Gronert J Arciszewska M Artemiuk E Blach E Blicharski T Cypryk K Dabrowska M Górny G Górska M Jakubowska I Jazwinska-tarnawska E Karczmarczyk A Kitowska-koterla J Koltowski L Krzyzagorska E Pasternak D Pentela-nowicka J Piesiewicz W Przekwas-jaruchowska M Rajzer M Salamon-ferenc A Sawicki A Skowron T ŚMiałowski A Tykarski A Albota A Alexandru C Crisan C Dumitrescu A Ferariu Ie Lupusoru Da Munteanu M Negru D Nicolau A Pintiliei E Popescu A Serban G Veresiu Ia Voitec M Babenko A Barbarash O Bondar I Chizhov P Demin A Dora S Dreval A Ershova O Gratsiansky N Ketova G Kotelnikov M Levashov S Morugova T Mustafina S Pekarskiy S Raskina T Rechkova E Samoylova Y Sazonova O Sherenkov A Shilkina N Stetsyuk O Tretyakova T Turova E Valeeva F Zadionchenko V Dalan R Tan Rs Tay L Buganova I Fabry J Jan C Krahulec B Toserova E Zak R Zimanova J Badat A Bester F Burgess L De Jong D Distiller L Ellis G Fouche L Govender P Govind U Naidoo V Nieuwoudt G Nortje H Rheeder P Robertson L Siddique N Stapelberg Am Trinder Y Van Der Merwe A Van Zyl L Viljoen M Wilhase A Botella M Civeira Murillo F De Teresa L Del Cañizo Fj Extremera Bg Gimeno Ej Martin-hidalgo A Morales C Nubiola A Rovira A Tinahones Madueño F Tranche S Trescolí Serrano C Alvarsson M Eizyk E Gillblad A Johansson P Löndahl M Ohlsson-önerud Å Rautio A Sundström U Torstensson I Chen Jf Chou Cw Chuang Lm Ho Lt Hsieh Ic Huang Bh Huang Cl Huang Cn Lai Wt Lo Ph Pei D Sheu Wh Wang Sy Araz M Bakiner O Comlekci A Delibasi T Guler S Sahin I Sarac F Tarkun I Ukinc K Yilmaz M Abdulhakim E Abraham P Adamson K Adler A Blagden M Bundy C Daly M Davies M Deshpande M Gillings S Harvey P Horvathova V Horvathova V Hristova D Jaap A Johnson A Jones H Kerrane J Kilvert A Ko T Kumar J Lindsay R Litchfield J Mccrimmon R Mcknight J Millward B Oyesile B Purewal T Ravikumar C Robinson A Sathyapalan T Simpson H Thomas H Turner W Weaver J Wilding J Wiles P Adkins K Akpunonu B Albu J Anagnostis G Anastasi L Argoud G Aroda V Azizad M Banerji Ma Bartkowiak A Jr Bays H Behn P Bergenstal R Bhargava A Bias D Bolster E Buchanan P Busch R Chadha C Chang M Cheng C Cohen A Cohen J Cole B Connery L Cooperman M Cushman W Dagostino R Davies M Dayamani P De Lemos J De Meireles M Dean J Dehart D Detweiler R Donovan D Dugano-daphnis P Dulin M Dunn F Eaton C Erickson B Estevez R Feinglos M Fonseca V Force R Forker A Fox D Gabriel J Garcia R Garvey T Gaudiani L Getaneh A Goff D Goldberg A Goldman S Hairston K Harris R Haught W Hidalgo H Jr Higgins A Houchin V Ison R Jacobs G Jaffrani N Jafry B Kapsner P Kaye W Labroo A Levinson L Lewis S Lillestol M Luttrell L Madu I Mcneill R Merrick B Metzger F Nadar V Nagelberg S Nash S Oparil S Osei K Papademetriou V Patel N Pedley C Prentiss A Radbill M Raisinghani A Rassouli N Reddy R Rees P Rendell M Robbins D Rodbard H Rohlf J Roseman H Rudolph L Sadler L Schnall A Schramm R Schubart U Seneviratne T Shanik M Snyder H Sorli C Stich M Sweeney Me Tsao J Ukwade P Viswanath D Vo A Vogel C Voyce S Weintraub H White J Wood M Wu P Wysham C Zimmerman R

subject

Oral medicine.medical_specialty Heart diseases Glycosylated Administration Oral heart failure Type 2 diabetes Dipeptidyl peptidase-4 inhibitor Kaplan-Meier Estimate Placebo Sitagliptin Phosphate Sitagliptin Cardiovascular Outcomes chemistry.chemical_compound Drug Therapy Double-Blind Method Internal medicine Diabetes Mellitus medicine Humans Hypoglycemic Agents Glycated Hemoglobin Hemoglobin A Glycosylated Administration Oral; Cardiovascular Diseases; Diabetes Mellitus Type 2; Double-Blind Method; Drug Therapy Combination; Follow-Up Studies; Heart Diseases; Heart Failure; Hemoglobin A Glycosylated; Hospitalization; Humans; Hypoglycemic Agents; Kaplan-Meier Estimate; Pyrazines; Sitagliptin Phosphate; Triazoles; Medicine (all)business.industry Medicine (all)Semaglutide Sitagliptin Phosphate Hemoglobin A General Medicine Triazoles ta3121 medicine.disease Surgery Hospitalization Cardiovascular diseases chemistry Diabetes Mellitus Type 2 Sitagliptin Pyrazines Administration Combination Drug Therapy Combination Glycated hemoglobin business Type 2 Alogliptin medicine.drug Follow-Up Studies

description

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to-0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P=0.98). There were no significant between-group differences in rates of acute pancreatitis (P=0.07) or pancreatic cancer (P=0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events. (Funded by Merck Sharp & Dohme; TECOS ClinicalTrials.gov number, NCT00790205.).

year	journal	country	edition	language
2015-07-16	New England Journal of Medicine

10.1056/nejmoa1501352 https://doi.org/10.1056/NEJMoa1501352