0000000000071365
AUTHOR
Nathalie André
Activités archéologiques de l'École française de Rome. Chronique. Année 2008.
Plan. Ill. en coul.; International audience
Exosomes released by keratinocytes modulate melanocyte pigmentation
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is…
Activités archéologiques de l'École française de Rome. Chronique. Année 2007.
Plan. Ill. en coul.; International audience