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RESEARCH PRODUCT
Exosomes released by keratinocytes modulate melanocyte pigmentation
Cédric DelevoyeGuillaume Van NielNathalie AndréFlorent DingliGraça RaposoAlessandra Lo CiceroDamarys LoewKatell ViéChristelle GuéréFloriane Gilles-marsenssubject
KeratinocytesProteomicsUltraviolet RaysGeneral Physics and AstronomyBiologyMelanocyteProteomicsExosomesReal-Time Polymerase Chain ReactionGeneral Biochemistry Genetics and Molecular BiologyArticleTandem Mass SpectrometrymedicineHumansSecretionRNA MessengerCells CulturedMelanosomeRegulation of gene expressionMelaninsMultidisciplinaryMelanosomesEpidermis (botany)PigmentationGeneral ChemistryMicrovesiclesCell biologyMicroscopy Electronmedicine.anatomical_structureGene Expression RegulationMicroscopy FluorescenceMelanocytesEpidermisIntracellularChromatography Liquiddescription
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-06-01 | Nature Communications |