Author: Alan Courteau

0000000000072082

AUTHOR

Alan Courteau

showing 4 related works from this author

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

2019

International audience; A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

Materials science[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/ImagingGeneral Chemical Engineering[SDV]Life Sciences [q-bio]NanoparticleNanotechnology[SDV.CAN]Life Sciences [q-bio]/Cancer02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences3. Good health0104 chemical scienceschemistry.chemical_compoundOptical imagingFunctionalized nanoparticleschemistryMichael reactionSurface modification[CHIM]Chemical SciencesChelationCyanine0210 nano-technology[CHIM.RADIO]Chemical Sciences/Radiochemistry

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Application of the optically stimulated luminescence (OSL) technique for mouse dosimetry in micro-CT imaging

2013

International audience; Purpose: Micro-CT is considered to be a powerful tool to investigate various models of disease on anesthetized animals. In longitudinal studies, the radiation dose delivered by the micro-CT to the same animal is a major concern as it could potentially induce spurious effects in experimental results. Optically stimulated luminescence dosimeters (OSLDs) are a relatively new kind of detector used in radiation dosimetry for medical applications. The aim of this work was to assess the dose delivered by the CT component of a micro-SPECT (single-photon emission computed tomography)/CT camera during a typical whole-body mouse study, using commercially available OSLDs based o…

[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging[ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging[INFO.INFO-IM] Computer Science [cs]/Medical Imaging[INFO.INFO-IM]Computer Science [cs]/Medical Imaging[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging

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Implementation of routine sequential PET/MR of the rat heart in an in-line preclinical scanner

2016

International audience

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Contributions to the physical and experimental validation of a simultaneous PET/MRI system dedicated to small animal imaging

2020

Simultaneous PET/MRI is a dynamic research field of both medical and preclinical domains. The ability of integrated systems to acquire the highly complementarity MR morphological and PET functional data in a single examination paves the way to innovative applications. The hereby document presents a series of experimentations dealing with the performance evaluation and the experimental in vivo capacities of such a device. Physical measurements were implemented based on international standards or inspired by articles of reference. The evaluated system consists of a compact SiPM-based PET subsystem fully integrated in a 7 T preclinical MRI based on the dry magnet technology. Experimentations s…

PerformancesPositron emission tomographyMagnetic resonance imaging[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing[INFO.INFO-TS] Computer Science [cs]/Signal and Image ProcessingPerformanceImagerie par résonance magnétiqueTomographie par émission de positonPrécliniqueInstrumentationPreclinical

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