Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

6533b854fe1ef96bd12aea18

RESEARCH PRODUCT

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

Alan Courteau Mathieu Moreau Vu-long Tran Vivek Thakare Franck Denat Eloise Thomas François Lux Olivier Tillement Frédéric Boschetti Anthony Romieu Anthony Romieu Marco Natuzzi Jean-marc Vrigneaud Bertrand Collin Cédric Louis Stéphane Roux

subject

Materials science [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging General Chemical Engineering [SDV]Life Sciences [q-bio]Nanoparticle Nanotechnology [SDV.CAN]Life Sciences [q-bio]/Cancer 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 3. Good health 0104 chemical sciences chemistry.chemical_compound Optical imaging Functionalized nanoparticles chemistry Michael reaction Surface modification [CHIM]Chemical Sciences Chelation Cyanine 0210 nano-technology [CHIM.RADIO]Chemical Sciences/Radiochemistry

description

International audience; A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

year	journal	country	edition	language
2019-08-09

10.1039/c9ra00365g https://hal.archives-ouvertes.fr/hal-02287597

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