0000000000073277
AUTHOR
T Terranova
Azione Dell'Insulina Sul Metabolismo Degli Organi Di Ratto Normale E Di Ratto Portatore Di Sarcoma Da Benzopirene
Normal rats and rats bearing benzpyrene sarcoma either initial (mean weight of the growth g 3.5) or advanced (mean weight g 30-50), were fasted for 24 hours and then given 4 I.U. insulin. Tissue free amino acids level, oxygen consumption, some oxidative enzymatic activities, glycogen, total phosphorus and labile ATP phosphorus of various organs have been studied following the insulin administration. A more or less appreciable difference in the insuline action on free amino acids and oxygen consumption was noticeable between tumour- bearing and normal animals; this difference is more marked in cases of advanced tumour. Of the various aminoacids taken into consideration, aspartic acid, gluta…
SUL METABOLISMO DEGLI ORGANI DI RATTO PORTATORE DI SARCOMA DA BENZOPIRENE
Free aminoacids were estimated in benzopyrene sarcoma of rats and in some organs of the tumour-bearing rats (brain, heart, muscle, lung, liver, spleen, kidney). In the tumour the content changes according to the growth stage; in the advanced tumour a strong increase of serine-glycine, glutammic acid and treonine is observed. In the organs the free amino acid contents are diminished in the first stages of the tumour growth, while in the advanced stages there is a tendency to an increase with different values according to the organs. The oxidation process in the organ homogenate (with or without substrate addition) varies according to the stage of the tumour growth, more evidently in the org…