0000000000073278
AUTHOR
Castro
Azione Dell'Insulina Sul Metabolismo Degli Organi Di Ratto Normale E Di Ratto Portatore Di Sarcoma Da Benzopirene
Normal rats and rats bearing benzpyrene sarcoma either initial (mean weight of the growth g 3.5) or advanced (mean weight g 30-50), were fasted for 24 hours and then given 4 I.U. insulin. Tissue free amino acids level, oxygen consumption, some oxidative enzymatic activities, glycogen, total phosphorus and labile ATP phosphorus of various organs have been studied following the insulin administration. A more or less appreciable difference in the insuline action on free amino acids and oxygen consumption was noticeable between tumour- bearing and normal animals; this difference is more marked in cases of advanced tumour. Of the various aminoacids taken into consideration, aspartic acid, gluta…
Interferon alfa-2b plus ribavirin for chronic hepatitis C patients who have not responded to interferon monotherapy
Background: The role of combination therapy is poorly defined in chronic hepatitis C patients who are non-responders to interferon. Aim: To assess the efficacy, safety and tolerance of interferon alfa-2b plus ribavirin in chronic hepatitis C patients who do not respond to interferon monotherapy. Methods: A total of 127 non-responder patients with chronic hepatitis C received 3 mU t.i.w. of interferon alfa-2b plus 1000–1200 mg ribavirin daily for 48 weeks. Effects of therapy were evaluated by serum aminotransferases and hepatitis C virus (HCV) RNA levels. Results: Twenty-nine (23%) patients had an end-of-treatment response. Six months after treatment, 20 (16%) patients were sustained respond…