P-Chirogenic Triazole-Based Phosphine: Synthesis, Coordination Chemistry, and Asymmetric Catalysis

Synthesis of ortho-fonctionnalized arylphosphines and their applications

This thesis reports with the synthesis of ortho-functionnalized phosphines bearing phosphonium and 1,2,3-triazole moieties.The synthesis of phosphines-phosphoniums, using as key-step Phospha-Fries rearrangement and Appel reaction is described. Eight new phosphines- phosphoniums, bearing aryl, alkyl or ferrocenyl fragments on the phosphonium part, have been prepared with overall yields reaching 48%. These phosphines- phosphoniums have been used in the preparation of gold (I) complexes which have been characterized using spectroscopic methods and X ray diffraction. Both gold (I) complexes and phosphines-phosphoniums have been studied in biology and these compounds turned out to be cytotoxic i…

CCDC 1953273: Experimental Crystal Structure Determination

Related Article: Jérôme Bayardon, Benjamin Rousselle, Yoann Rousselin, Quentin Bonnin, Raluca Malacea-Kabbara|2020|Eur.J.Org.Chem.|2020|4723|doi:10.1002/ejoc.202000723

CCDC 1953272: Experimental Crystal Structure Determination

Related Article: Jérôme Bayardon, Benjamin Rousselle, Yoann Rousselin, Quentin Bonnin, Raluca Malacea-Kabbara|2020|Eur.J.Org.Chem.|2020|4723|doi:10.1002/ejoc.202000723