0000000000073758
AUTHOR
G.a. Rivas
Simultaneous Determination of Adrenaline and Noradrenaline by First Derivative Spectrophotometry in a Fia Assembly
Abstract This article deals with the design of an unsegmented-flow injection manifold for the simultaneous determination of adrenaline and noradrenaline two structurally related compounds with overlapping spectra. An FIA manifold is proposed for the simultaneous determination in which the sample solution is directly injected into a carrier-reagent stream of aqueous NaOH. The selected wavelengths (first derivative) were 394 and 342 nm, for noradrenaline and adrenaline, respectively with an integration time of 0.4 s. The calibration graphs are linear over the range 2.0–30 ppm for both drugs. The method is applied to different synthetic mixtures of both drugs.
FIA-AAS determination of salicylic acid by a solid-phase reactor of copper carbonate incorporated in polyester resin beads.
Abstract The determination of salicylic acid was carried out by reaction of the drug with copper carbonate entrapped in a polymeric material in a solid-phase reactor; the released cupric ions were monitored by flame atomic absorption at 324.8 nm. The calibration graph is linear over the range 4.0–75 μg ml −1 of salicylic acid, with a relative standard deviation of less than 1.5% and a sample throughout of 257 h −1 . The influence of foreign compounds was studied and the method was applied to the determination of salicylic acid content in two different pharmaceutical formulations.