AIOC2: A deep Q-learning approach to autonomic I/O congestion control in Lustre

Abstract In high performance computing systems, I/O congestion is a common problem in large-scale distributed file systems. However, the current implementation mainly requires administrator to manually design low-level implementation and optimization, we proposes an adaptive I/O congestion control framework, named AIOC 2 , which can not only adaptively tune the I/O congestion control parameters, but also exploit the deep Q-learning method to start the training parameters and optimize the tuning for different types of workloads from the server and the client at the same time. AIOC 2 combines the feedback-based dynamic I/O congestion control and deep Q-learning parameter tuning technology to …

Improving LSM‐trie performance by parallel search

Mutation ofPOC1Bin a Severe Syndromic Retinal Ciliopathy

We describe a consanguineous Iraqi family with Leber congenital amaurosis (LCA), Joubert syndrome (JBTS), and polycystic kidney disease (PKD). Targeted next-generation sequencing for excluding mutations in known LCA and JBTS genes, homozygosity mapping, and whole-exome sequencing identified a homozygous missense variant, c.317G>C (p.Arg106Pro), in POC1B, a gene essential for ciliogenesis, basal body, and centrosome integrity. In silico modeling suggested a requirement of p.Arg106 for the formation of the third WD40 repeat and a protein interaction interface. In human and mouse retina, POC1B localized to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in …

The association of calcium intake with osteoporotic vertebral fractures in a large Chinese cohort

The effect of calcium on prevention of osteoporosis and related fracture which are aging issues is unclear. The aim of this study is to explore the association of calcium intake with vertebral fracture. This study enrolled 3,457 participants from China Action on Spine and Hip Status (CASH) study from 2013 and 2017. Dietary calcium intake was collected using validated food frequency questionnaires (FFQ). Vertebral fracture of CT images was defined as the primary outcome. The mean calcium intake of men and women were 522.75mg/day and 507.21mg/day, respectively. 6% reduction in the odds of fracture risk was observed per 100 unit increase of calcium intake from food among females (OR, 0.94; 95%…

Characteristics of patients seeking outpatient smoking cessation treatment before and after the implementation of a smoke-free law in Valencia (Spain): a cross-sectional study

ObjectiveExplore potential changes in the characteristics of patients requesting smoking cessation treatment at an outpatient setting in Spain before and after Law 42/2010 was enacted.DesignThis is a cross-sectional study with convenience sampling. The information was obtained from the medical records of patients receiving smoking cessation treatment from January 2008 to December 2014.SettingHospital Clinico Universitario de Valencia.Participants423 patients who sought smoking cessation treatment 36 months before or 48 months after the enactment of the law.ResultsAfter the enactment of a comprehensive smoke-free law in Spain, the patients seeking smoking cessation treatment were older (p=0.…

Estudio epidemiológico de encuestas y escalas en el tratamiento multicomponente sobre un colectivo de pacientes fumadores de la comunidad valenciana

Actualmente, el consumo de tabaco es la principal causa de morbimortalidad en los hombres y el segundo factor de riesgo de las mujeres en el mundo. Como una enfermedad de dependencia combina elementos farmacológicos, sociales y psicológicos, el tabaquismo no solo provoca enfermedades crónicas del organismo, también ha sido considerada una amenaza epidemiológica para toda la sociedad debido a los efectos nocivos generales en patología, economía y psicología, etc. Por ello, las investigaciones sobre el tratamiento de tabaquismo son muy importantes y tienen un valor considerable sobre la sanidad y la sociedad. Realizamos una investigación epidemiológica observacional, longitudinal y prospectiv…

Venous thromboembolism after oral and maxillofacial oncologic surgery: Report and analysis of 14 cases in Chinese population.

Background Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) is a leading cause of death in cancer patients. The aim of this study was to explore the potential risk factor of VTE in oral and maxillofacial oncological surgery. Material and Methods The data of patients who received operation in our institution were gathered in this retrospective study. A diagnosis of VTE was screened and confirmed by computer tomography angiography (CTA) of pulmonary artery or ultrasonography examination of lower extremity. Medical history and all perioperative details were analyzed. Results 14 patients were diagnosed as VTE, including 6 cases of PE, 7 cases of DVT,…

Evaluación de un programa de actividad física en adultos mayores no institucionalizados

La actividad física es uno de los hábitos clave que influyen en el envejecimiento saludable, según la OMS. El objetivo de este estudio fue evaluar el efecto en la esfera funcional de un programa de actividad física realizado en el contexto de un taller de envejecimiento activo. Se realizó un estudio de diseño de preintervención y posintervención en un solo grupo. Se incluyeron 54 adultos sanos, no institucionalizados, de edad igual o mayor a 60 años. El programa de actividad física consistió en 90 sesiones grupales bisemanales, de 45-60 minutos de duración, realizadas durante 45 semanas. Los participantes realizaron estiramientos y ejercicios aeróbicos y de tonificación muscular de intensid…