0000000000075557

AUTHOR

Di Stefano M

showing 5 related works from this author

Biocompatible Polymers and Processing Techniques in Drug Delivery and Tissue Engineering

2013

World Wide WebBiocompatible polymersTissue engineeringPolymers Tissue Engineering Atom Transfer Radical Polymerization bioengineered tissue electrospinningChemistryOpen access publishingDrug deliveryNanotechnologyJournal of Pharmaceutics and Drug Development
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Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation.

2015

Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: O…

AdultMalemedicine.medical_specialtyAbdominal painConstipationConstipation severityChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational Health; Medicine (all)Reproducibility of ResultChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational HealthQuality of lifeInternal medicineSurveys and QuestionnairesmedicineCriterion validitySurveys and QuestionnaireHumansChronic constipationSettore MED/12 - Gastroenterologiabusiness.industryChronic constipationMinimal clinically important differenceMedicine (all)Environmental and Occupational HealthSettore MED/09 - MEDICINA INTERNAPublic Health Environmental and Occupational HealthReproducibility of ResultsStatisticalMiddle Agedmedicine.diseaseConfirmatory factor analysisSettore MED/18 - Chirurgia GeneraleChronic DiseasePhysical therapyQuality of LifeFunctional constipationChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Public Health Environmental and Occupational HealthChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis StatisticalFemalePublic HealthChronic non-organic constipationPatient Caremedicine.symptombusinessFactor Analysis StatisticalFactor AnalysisConstipationHumanQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
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Two novel mutations at exon 8 of Sequestosome 1 gene (SQSTM 1)in an Italian series of patient affected by Paget’s disease of bone (PDB)

2004

PDB is genetically heterogeneous. Mutations of the sequestosome1 gene have been reported in sporadic and familial forms of Paget's in patients of French Canadian and British descent. Mutational analyses in different ethnic groups are needed to accurately investigate hereditary diseases. We describe two novel mutations of sequestosome1 in 62 Italian sporadic patients, confirming the role of the encoded protein in this disorder. INTRODUCTION: Paget's disease of bone (PDB) is a relatively common disease of bone metabolism reported to affect up to 3% of whites over 55 years of age. The disorder is genetically heterogeneous, and at present, there is scientific evidence that at least eight differ…

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Interoperabiity

2008

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Mutations of p62/Sequestosome 1 Gene (p62/SQSTM1) in 4 Italian Families Affected by Paget’s Disease of Bone (PDB)

2004

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