0000000000075897

AUTHOR

Andreas Neiser

showing 3 related works from this author

Single Particle Plasmon Sensors as Label-Free Technique To Monitor MinDE Protein Wave Propagation on Membranes.

2016

We use individual gold nanorods as pointlike detectors for the intrinsic dynamics of an oscillating biological system. We chose the pattern forming MinDE protein system from Escherichia coli (E. coli), a prominent example for self-organized chemical oscillations of membrane-associated proteins that are involved in the bacterial cell division process. Similar to surface plasmon resonance (SPR), the gold nanorods report changes in their protein surface coverage without the need for fluorescence labeling, a technique we refer to as NanoSPR. Comparing the dynamics for fluorescence labeled and unlabeled proteins, we find a reduction of the oscillation period by about 20%. The absence of photoble…

0301 basic medicineLipid BilayersAnalytical chemistryBioengineeringCell Cycle Proteins02 engineering and technologyBiosensing Techniques03 medical and health sciencesMin SystemEscherichia coliGeneral Materials ScienceSurface plasmon resonancePlasmonFluorescent DyesAdenosine TriphosphatasesNanotubesOscillationChemistryMechanical EngineeringEscherichia coli ProteinsGeneral ChemistrySurface Plasmon Resonance021001 nanoscience & nanotechnologyCondensed Matter PhysicsFluorescencePhotobleaching030104 developmental biologyBiophysicsNanorodGold0210 nano-technologyBiosensorNano letters
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Multiplexed plasmon sensor for rapid label-free analyte detection.

2013

Efficient and cost-effective multiplexed detection schemes for proteins in small liquid samples would bring drastic advances to fields like disease detection or water quality monitoring. We present a novel multiplexed sensor with randomly deposited aptamer functionalized gold nanorods. The spectral position of plasmon resonances of individual nanorods, monitored by dark-field spectroscopy, respond specifically to different proteins. We demonstrate nanomolar sensitivity, sensor recycling, and the potential to upscale to hundreds or thousands of targets.

AnalyteMaterials scienceAptamerNanophotonicsProtein Array AnalysisBioengineeringNanotechnology02 engineering and technologyBiosensing Techniques010402 general chemistry01 natural sciencesMultiplexingNanotechnologyGeneral Materials ScienceSpectroscopyPlasmonLabel freeStaining and LabelingMechanical EngineeringProteinsGeneral ChemistryEquipment DesignSurface Plasmon Resonance021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesEquipment Failure AnalysisNanorod0210 nano-technologyNano letters
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Narrowing the Plasmonic Sensitivity Distribution by Considering the Individual Size of Gold Nanorods

2018

The plasmonic nanoparticle sensitivity, sensing volume, and the signal-to-noise ratio are strongly dependent on the nanoparticle dimensions. It is difficult to chemically produce or purify nanoparticles with a size variation of less than 10%. This size variation induces a systematic error in sensing experiments that can be reduced when the exact size of each individual nanoparticle is known. In this work, we show how the size of gold nanorods can be estimated directly from the optical spectra of single nanoparticles by using the increase of radiation damping with the nanoparticle size. We verify our approach by comparing these spectrally estimated sizes with the precise sizes of exactly the…

Materials sciencebusiness.industryScanning electron microscopePhysics::Medical PhysicsPhysics::OpticsNanoparticle02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsGeneral EnergyRadiation dampingColloidal goldOptoelectronicsParticleNanorodSensitivity (control systems)Physical and Theoretical Chemistry0210 nano-technologybusinessPlasmonThe Journal of Physical Chemistry C
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