6533b823fe1ef96bd127e17b
RESEARCH PRODUCT
Multiplexed plasmon sensor for rapid label-free analyte detection.
Jonathan EdgarAndreas NeiserCarsten SönnichsenAndreas HenkelChristina RosmanJanak Prasadsubject
AnalyteMaterials scienceAptamerNanophotonicsProtein Array AnalysisBioengineeringNanotechnology02 engineering and technologyBiosensing Techniques010402 general chemistry01 natural sciencesMultiplexingNanotechnologyGeneral Materials ScienceSpectroscopyPlasmonLabel freeStaining and LabelingMechanical EngineeringProteinsGeneral ChemistryEquipment DesignSurface Plasmon Resonance021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesEquipment Failure AnalysisNanorod0210 nano-technologydescription
Efficient and cost-effective multiplexed detection schemes for proteins in small liquid samples would bring drastic advances to fields like disease detection or water quality monitoring. We present a novel multiplexed sensor with randomly deposited aptamer functionalized gold nanorods. The spectral position of plasmon resonances of individual nanorods, monitored by dark-field spectroscopy, respond specifically to different proteins. We demonstrate nanomolar sensitivity, sensor recycling, and the potential to upscale to hundreds or thousands of targets.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-25 | Nano letters |