0000000000077476

AUTHOR

Silvia Grimaldi

showing 4 related works from this author

Effects of levodopa oral bolus on the kinematics of the pointing movements in Parkinson's disease patients.

2005

We studied the time-course of a levodopa oral bolus effects on the kinematics of patients affected by a mild akinetic-rigid form of idiopathic Parkinson's disease (PD). Eleven PD patients were evaluated: a) in OFF-state, that is before their first medication or after its withdrawal, b) in ON-state, that is at 1/2, 1, 2, 3, 4, 5, 6, 24, 30 and 48 hours after the administration of 250 mg of levodopa plus 25mg of carbidopa. The main kinematics (i. e.movement time, peak of velocity, peak of acceleration and peak of deceleration) of pointing movements to six target-stimuli placed on the horizontal plane of a table were recorded. Clinical conditions were assessed according to the Motor Examinatio…

AdultMaleLevodopamedicine.medical_specialtyTime FactorsNeurologyParkinson's diseaseAdministration Oralparkinson's diesease clinical neurophysiology kinematicsKinematicsClinical neurophysiologyAntiparkinson AgentsLevodopaCentral nervous system diseaseBolus (medicine)Internal medicinemedicineHumansAgedbusiness.industryParkinson DiseaseMiddle Agedmedicine.diseaseBiomechanical PhenomenaSurgeryNeurologyCarbidopaCardiologyFemaleSettore MED/26 - NeurologiaNeurology (clinical)businessPsychomotor Performancemedicine.drug
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Movements Execution in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

2007

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunct…

Malemedicine.medical_specialtyMild Cognitive ImpairmentMotor dysfunctionneuropsychologyNeurosciences. Biological psychiatry. NeuropsychiatryDiseaseAudiologyNeuropsychological TestsMotor behaviourSeverity of Illness Indexbehavioral disciplines and activitiesAlzheimer Diseasemental disordersmedicineReaction TimeHumansBiomechanicsClinical NoteAlzheimer’s DiseaseCognitive impairmentalzheimer's disease mild cognitive impairment kinematicsAgedDemographypointingMovement DisordersNeuropsychologyCognitionGeneral MedicineControl subjectsBiomechanical PhenomenaSeverity of Illness Index; Humans; Alzheimer Disease; Aged; Mental Recall; Cognition Disorders; Demography; Movement Disorders; Neuropsychological Tests; Amnesia; Biomechanics; Female; Male; Reaction TimeNeuropsychology and Physiological PsychologyNeurologykinematicsMental RecallSettore MED/26 - NeurologiaFemaleNeurology (clinical)AmnesiaPsychologyCognition DisordersNeuroscienceMovement planningRC321-571Behavioural Neurology
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The largest caucasian kindred with dentatorubral-pallidoluysian atrophy: A founder mutation in italy

2019

BACKGROUND: Dentatorubral-pallidoluysian atrophy is a hereditary neurodegenerative disease prevalently reported in Japan but rare in Caucasians. The objective of this study was to reconstruct the pedigree of Italian dentatorubral-pallidoluysian atrophy familial cases describing their clinical features. METHODS: We investigated 6 apparently unrelated dentatorubral-pallidoluysian atrophy families comprising a total of 51 affected individuals: 13 patients were clinically examined, and for 38 patients clinical data were collected from clinical sources. The dentatorubral-pallidoluysian atrophy diagnosis was genetically confirmed in 18 patients. Genealogical data from historical archives were ana…

0301 basic medicineAdultMalePediatricsmedicine.medical_specialtyAdolescentDiseaseNeuropsychological TestsWhite People03 medical and health sciencesEpilepsyYoung Adult0302 clinical medicineAtrophyTrinucleotide Repeatsdentatorubral-pallidoluysian atrophymedicineHumansFamilyATN1 geneChildFounder mutationAgedDentatorubral-pallidoluysian atrophyEpilepsybusiness.industrygenealogical methodMiddle Agedmedicine.diseaseMyoclonic Epilepsies ProgressivePedigree030104 developmental biologyfounder effectNeurologyCerebellar cognitive affective syndromeItalycerebellar cognitive-affective syndromeMutationFemaleNeurology (clinical)business030217 neurology & neurosurgeryFounder effect
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Grasp with hand and mouth: a kinematic study on healthy subjects

2001

Neurons involved in grasp preparation with hand and mouth were previously recorded in the premotor cortex of monkey. The aim of the present kinematic study was to determine whether a unique planning underlies the act of grasping with hand and mouth in humans as well. In a set of four experiments, healthy subjects reached and grasped with the hand an object of different size while opening the mouth ( experiments 1 and 3), or extending the other forearm ( experiment 4), or the fingers of the other hand ( experiment 5). In a subsequent set of three experiments, subjects grasped an object of different size with the mouth, while opening the fingers of the right hand ( experiments 6–8). The init…

AdultMalemedicine.medical_specialtyPhysiologyMovementKinematicsMotor NeuronFunctional LateralityBiomechanical PhenomenaPremotor cortexFingersPhysical medicine and rehabilitationmedicineFingerHumansSpeechMotor NeuronsCommunicationMouthHand Strengthbusiness.industryGeneral NeuroscienceGRASPHealthy subjectsMotor CortexBiomechanical PhenomenaFrontal Lobebody regionsmedicine.anatomical_structureFemalePsychologybusinesspsychological phenomena and processesAutomatic word reading; human kinematics; reaching-grasping; Broca's areaHuman
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